Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

The HIRA histone chaperone complex is involved in the deposition of the histone variant H3.3. Here the authors, by using biochemical and crystallographic approaches, report the homotrimerization of the HIRA subunit which is critical for the functional activity of the complex.

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Autores principales:	Dominique Ray-Gallet, M. Daniel Ricketts, Yukari Sato, Kushol Gupta, Ekaterina Boyarchuk, Toshiya Senda, Ronen Marmorstein, Geneviève Almouzni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71022acda3b54be6ad946c83a4006f44
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spelling	oai:doaj.org-article:71022acda3b54be6ad946c83a4006f442021-12-02T16:56:38ZFunctional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit10.1038/s41467-018-05581-y2041-1723https://doaj.org/article/71022acda3b54be6ad946c83a4006f442018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05581-yhttps://doaj.org/toc/2041-1723The HIRA histone chaperone complex is involved in the deposition of the histone variant H3.3. Here the authors, by using biochemical and crystallographic approaches, report the homotrimerization of the HIRA subunit which is critical for the functional activity of the complex.Dominique Ray-GalletM. Daniel RickettsYukari SatoKushol GuptaEkaterina BoyarchukToshiya SendaRonen MarmorsteinGeneviève AlmouzniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dominique Ray-Gallet M. Daniel Ricketts Yukari Sato Kushol Gupta Ekaterina Boyarchuk Toshiya Senda Ronen Marmorstein Geneviève Almouzni Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
description	The HIRA histone chaperone complex is involved in the deposition of the histone variant H3.3. Here the authors, by using biochemical and crystallographic approaches, report the homotrimerization of the HIRA subunit which is critical for the functional activity of the complex.
format	article
author	Dominique Ray-Gallet M. Daniel Ricketts Yukari Sato Kushol Gupta Ekaterina Boyarchuk Toshiya Senda Ronen Marmorstein Geneviève Almouzni
author_facet	Dominique Ray-Gallet M. Daniel Ricketts Yukari Sato Kushol Gupta Ekaterina Boyarchuk Toshiya Senda Ronen Marmorstein Geneviève Almouzni
author_sort	Dominique Ray-Gallet
title	Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
title_short	Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
title_full	Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
title_fullStr	Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
title_full_unstemmed	Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit
title_sort	functional activity of the h3.3 histone chaperone complex hira requires trimerization of the hira subunit
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/71022acda3b54be6ad946c83a4006f44
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Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

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