Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique

Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique

Navideh Anarjan,1 Hoda Jafarizadeh-Malmiri,2 Imededdine Arbi Nehdi,3 Hassen Mohamed Sbihi,3 Saud Ibrahim Al-Resayes,3 Chin Ping Tan4 1Young Researchers And Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran; 2Department of Chemical Engineering, Faculty of Food Engineering, Sahand Uni...

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Autores principales: Anarjan N, Jafarizadeh-Malmiri H, Nehdi IA, Sbihi HM, Al-Resayes SI, Tan CP
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/7107995e3cb4450489b20560c170df87
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spelling oai:doaj.org-article:7107995e3cb4450489b20560c170df872021-12-02T02:37:30ZEffects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique1178-2013https://doaj.org/article/7107995e3cb4450489b20560c170df872015-02-01T00:00:00Zhttp://www.dovepress.com/effects-of-homogenization-processnbspparameters-on-physicochemical-pro-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Navideh Anarjan,1 Hoda Jafarizadeh-Malmiri,2 Imededdine Arbi Nehdi,3 Hassen Mohamed Sbihi,3 Saud Ibrahim Al-Resayes,3 Chin Ping Tan4 1Young Researchers And Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran; 2Department of Chemical Engineering, Faculty of Food Engineering, Sahand University of Technology, Tabriz, Iran; 3King Saud University, College of Science, Chemistry Department, Riyadh, Saudi Arabia; 4Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia Abstract: Nanodispersion systems allow incorporation of lipophilic bioactives, such as astaxanthin (a fat soluble carotenoid) into aqueous systems, which can improve their solubility, bioavailability, and stability, and widen their uses in water-based pharmaceutical and food products. In this study, response surface methodology was used to investigate the influences of homogenization time (0.5–20 minutes) and speed (1,000–9,000 rpm) in the formation of astaxanthin nanodispersions via the solvent-diffusion process. The product was characterized for particle size and astaxanthin concentration using laser diffraction particle size analysis and high performance liquid chromatography, respectively. Relatively high determination coefficients (ranging from 0.896 to 0.969) were obtained for all suggested polynomial regression models. The overall optimal homogenization conditions were determined by multiple response optimization analysis to be 6,000 rpm for 7 minutes. In vitro cellular uptake of astaxanthin from the suggested individual and multiple optimized astaxanthin nanodispersions was also evaluated. The cellular uptake of astaxanthin was found to be considerably increased (by more than five times) as it became incorporated into optimum nanodispersion systems. The lack of a significant difference between predicted and experimental values confirms the suitability of the regression equations connecting the response variables studied to the independent parameters. Keywords: optimization, lipophilic bioactive nanodispersions, response surface methodologyAnarjan NJafarizadeh-Malmiri HNehdi IASbihi HMAl-Resayes SITan CPDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 1109-1118 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Anarjan N
Jafarizadeh-Malmiri H
Nehdi IA
Sbihi HM
Al-Resayes SI
Tan CP
Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique
description Navideh Anarjan,1 Hoda Jafarizadeh-Malmiri,2 Imededdine Arbi Nehdi,3 Hassen Mohamed Sbihi,3 Saud Ibrahim Al-Resayes,3 Chin Ping Tan4 1Young Researchers And Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran; 2Department of Chemical Engineering, Faculty of Food Engineering, Sahand University of Technology, Tabriz, Iran; 3King Saud University, College of Science, Chemistry Department, Riyadh, Saudi Arabia; 4Department of Food Technology, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia Abstract: Nanodispersion systems allow incorporation of lipophilic bioactives, such as astaxanthin (a fat soluble carotenoid) into aqueous systems, which can improve their solubility, bioavailability, and stability, and widen their uses in water-based pharmaceutical and food products. In this study, response surface methodology was used to investigate the influences of homogenization time (0.5–20 minutes) and speed (1,000–9,000 rpm) in the formation of astaxanthin nanodispersions via the solvent-diffusion process. The product was characterized for particle size and astaxanthin concentration using laser diffraction particle size analysis and high performance liquid chromatography, respectively. Relatively high determination coefficients (ranging from 0.896 to 0.969) were obtained for all suggested polynomial regression models. The overall optimal homogenization conditions were determined by multiple response optimization analysis to be 6,000 rpm for 7 minutes. In vitro cellular uptake of astaxanthin from the suggested individual and multiple optimized astaxanthin nanodispersions was also evaluated. The cellular uptake of astaxanthin was found to be considerably increased (by more than five times) as it became incorporated into optimum nanodispersion systems. The lack of a significant difference between predicted and experimental values confirms the suitability of the regression equations connecting the response variables studied to the independent parameters. Keywords: optimization, lipophilic bioactive nanodispersions, response surface methodology
format article
author Anarjan N
Jafarizadeh-Malmiri H
Nehdi IA
Sbihi HM
Al-Resayes SI
Tan CP
author_facet Anarjan N
Jafarizadeh-Malmiri H
Nehdi IA
Sbihi HM
Al-Resayes SI
Tan CP
author_sort Anarjan N
title Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique
title_short Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique
title_full Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique
title_fullStr Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique
title_full_unstemmed Effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique
title_sort effects of homogenization process parameters on physicochemical properties of astaxanthin nanodispersions prepared using a solvent-diffusion technique
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/7107995e3cb4450489b20560c170df87
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