Control of enzyme reactions by a reconfigurable DNA nanovault

DNA nanostructures can cage enzymes but currently fall short of controlling their reactions with substrates. Here, the authors enclose an enzyme inside a dynamic DNA vault, which regulates its access to substrate molecules—and thus its enzymatic activity—through a multi-lock mechanism.

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Autores principales:	Guido Grossi, Mette Dalgaard Ebbesen Jepsen, Jørgen Kjems, Ebbe Sloth Andersen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7107fb1b97df46ccb741258961b57f28
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spelling	oai:doaj.org-article:7107fb1b97df46ccb741258961b57f282021-12-02T14:42:00ZControl of enzyme reactions by a reconfigurable DNA nanovault10.1038/s41467-017-01072-82041-1723https://doaj.org/article/7107fb1b97df46ccb741258961b57f282017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01072-8https://doaj.org/toc/2041-1723DNA nanostructures can cage enzymes but currently fall short of controlling their reactions with substrates. Here, the authors enclose an enzyme inside a dynamic DNA vault, which regulates its access to substrate molecules—and thus its enzymatic activity—through a multi-lock mechanism.Guido GrossiMette Dalgaard Ebbesen JepsenJørgen KjemsEbbe Sloth AndersenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guido Grossi Mette Dalgaard Ebbesen Jepsen Jørgen Kjems Ebbe Sloth Andersen Control of enzyme reactions by a reconfigurable DNA nanovault
description	DNA nanostructures can cage enzymes but currently fall short of controlling their reactions with substrates. Here, the authors enclose an enzyme inside a dynamic DNA vault, which regulates its access to substrate molecules—and thus its enzymatic activity—through a multi-lock mechanism.
format	article
author	Guido Grossi Mette Dalgaard Ebbesen Jepsen Jørgen Kjems Ebbe Sloth Andersen
author_facet	Guido Grossi Mette Dalgaard Ebbesen Jepsen Jørgen Kjems Ebbe Sloth Andersen
author_sort	Guido Grossi
title	Control of enzyme reactions by a reconfigurable DNA nanovault
title_short	Control of enzyme reactions by a reconfigurable DNA nanovault
title_full	Control of enzyme reactions by a reconfigurable DNA nanovault
title_fullStr	Control of enzyme reactions by a reconfigurable DNA nanovault
title_full_unstemmed	Control of enzyme reactions by a reconfigurable DNA nanovault
title_sort	control of enzyme reactions by a reconfigurable dna nanovault
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7107fb1b97df46ccb741258961b57f28
work_keys_str_mv	AT guidogrossi controlofenzymereactionsbyareconfigurablednananovault AT mettedalgaardebbesenjepsen controlofenzymereactionsbyareconfigurablednananovault AT jørgenkjems controlofenzymereactionsbyareconfigurablednananovault AT ebbeslothandersen controlofenzymereactionsbyareconfigurablednananovault
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Control of enzyme reactions by a reconfigurable DNA nanovault

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