Control of enzyme reactions by a reconfigurable DNA nanovault

DNA nanostructures can cage enzymes but currently fall short of controlling their reactions with substrates. Here, the authors enclose an enzyme inside a dynamic DNA vault, which regulates its access to substrate molecules—and thus its enzymatic activity—through a multi-lock mechanism.

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Auteurs principaux: Guido Grossi, Mette Dalgaard Ebbesen Jepsen, Jørgen Kjems, Ebbe Sloth Andersen
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/7107fb1b97df46ccb741258961b57f28
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