Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes
This study investigated the sex-specific differences in the correlation between intestinal microbiota and end-stage renal disease. Here, we compared the differences in the gut microbiota of male and female healthy controls (HC) and patients with end-stage renal disease (ESRD) caused by immunoglobuli...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/710942355da14d93bf3d49ef6e115694 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:710942355da14d93bf3d49ef6e115694 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:710942355da14d93bf3d49ef6e1156942021-12-01T05:53:04ZSex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes1664-302X10.3389/fmicb.2021.752393https://doaj.org/article/710942355da14d93bf3d49ef6e1156942021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.752393/fullhttps://doaj.org/toc/1664-302XThis study investigated the sex-specific differences in the correlation between intestinal microbiota and end-stage renal disease. Here, we compared the differences in the gut microbiota of male and female healthy controls (HC) and patients with end-stage renal disease (ESRD) caused by immunoglobulin A (IgA) nephropathy (ESRD-IgAN) or type-2 diabetes mellitus (ESRD-T2DM) using high-throughput sequencing of the 16S rRNA gene. We also analyzed the correlation between gut microbiota and clinical immune indicators. We assigned 8, 10, 5, 7, 11, and 20 volunteers to female HC, ESRD-IgAN, and ESRD-T2DM, and male HC, ESRD-IgAN, and ESRD-T2DM, respectively. The results showed sex-specific differences in both physiological and biochemical indices and intestinal microbiota composition, as well as the correlation between them. The correlations between physiological and biochemical indices in men were significantly lower than those in women, especially for indices related to immunity, blood glucose, and cardiac color sonography. Urine output, lymphocyte ratio, serum albumin, blood calcium, dialysis status, serum urea nitrogen, urine protein, and diabetes significantly correlated with male fecal microbiota composition, whereas only creatinine and 2-h post-prandial blood glucose significantly correlated with female fecal microbiota composition. The top 50 dominant operational taxonomic units showed a stronger correlation with physiological and biochemical indices in samples obtained from females than from males. These differences highlight sex-specific differences in the effectiveness of ESRD prevention and treatments via regulating intestinal microbiota.Peng ZhangJiali FangGuanghui LiLei ZhangXingqiang LaiLu XuLuhao LiuYunyi XiongLi LiTao ZhangJiao WanHailin XuRongxin ChenWeiting ZhangJunjie MaZheng ChenFrontiers Media S.A.articleend-stage renal diseaseIgA nephropathytype-2 diabetes mellitusgut microbiotaclinical immune indicatorschronic kidney diseaseMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
end-stage renal disease IgA nephropathy type-2 diabetes mellitus gut microbiota clinical immune indicators chronic kidney disease Microbiology QR1-502 |
| spellingShingle |
end-stage renal disease IgA nephropathy type-2 diabetes mellitus gut microbiota clinical immune indicators chronic kidney disease Microbiology QR1-502 Peng Zhang Jiali Fang Guanghui Li Lei Zhang Xingqiang Lai Lu Xu Luhao Liu Yunyi Xiong Li Li Tao Zhang Jiao Wan Hailin Xu Rongxin Chen Weiting Zhang Junjie Ma Zheng Chen Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes |
| description |
This study investigated the sex-specific differences in the correlation between intestinal microbiota and end-stage renal disease. Here, we compared the differences in the gut microbiota of male and female healthy controls (HC) and patients with end-stage renal disease (ESRD) caused by immunoglobulin A (IgA) nephropathy (ESRD-IgAN) or type-2 diabetes mellitus (ESRD-T2DM) using high-throughput sequencing of the 16S rRNA gene. We also analyzed the correlation between gut microbiota and clinical immune indicators. We assigned 8, 10, 5, 7, 11, and 20 volunteers to female HC, ESRD-IgAN, and ESRD-T2DM, and male HC, ESRD-IgAN, and ESRD-T2DM, respectively. The results showed sex-specific differences in both physiological and biochemical indices and intestinal microbiota composition, as well as the correlation between them. The correlations between physiological and biochemical indices in men were significantly lower than those in women, especially for indices related to immunity, blood glucose, and cardiac color sonography. Urine output, lymphocyte ratio, serum albumin, blood calcium, dialysis status, serum urea nitrogen, urine protein, and diabetes significantly correlated with male fecal microbiota composition, whereas only creatinine and 2-h post-prandial blood glucose significantly correlated with female fecal microbiota composition. The top 50 dominant operational taxonomic units showed a stronger correlation with physiological and biochemical indices in samples obtained from females than from males. These differences highlight sex-specific differences in the effectiveness of ESRD prevention and treatments via regulating intestinal microbiota. |
| format |
article |
| author |
Peng Zhang Jiali Fang Guanghui Li Lei Zhang Xingqiang Lai Lu Xu Luhao Liu Yunyi Xiong Li Li Tao Zhang Jiao Wan Hailin Xu Rongxin Chen Weiting Zhang Junjie Ma Zheng Chen |
| author_facet |
Peng Zhang Jiali Fang Guanghui Li Lei Zhang Xingqiang Lai Lu Xu Luhao Liu Yunyi Xiong Li Li Tao Zhang Jiao Wan Hailin Xu Rongxin Chen Weiting Zhang Junjie Ma Zheng Chen |
| author_sort |
Peng Zhang |
| title |
Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes |
| title_short |
Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes |
| title_full |
Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes |
| title_fullStr |
Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes |
| title_full_unstemmed |
Sex Differences in Fecal Microbiota Correlation With Physiological and Biochemical Indices Associated With End-Stage Renal Disease Caused by Immunoglobulin a Nephropathy or Diabetes |
| title_sort |
sex differences in fecal microbiota correlation with physiological and biochemical indices associated with end-stage renal disease caused by immunoglobulin a nephropathy or diabetes |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/710942355da14d93bf3d49ef6e115694 |
| work_keys_str_mv |
AT pengzhang sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT jialifang sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT guanghuili sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT leizhang sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT xingqianglai sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT luxu sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT luhaoliu sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT yunyixiong sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT lili sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT taozhang sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT jiaowan sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT hailinxu sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT rongxinchen sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT weitingzhang sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT junjiema sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes AT zhengchen sexdifferencesinfecalmicrobiotacorrelationwithphysiologicalandbiochemicalindicesassociatedwithendstagerenaldiseasecausedbyimmunoglobulinanephropathyordiabetes |
| _version_ |
1718405481459875840 |