Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents

The electron-withdrawing target (EWT)-induced fluorescence quenching is an unsolved issue in intramolecular charge transfer (ICT) fluorophores that limits their applicability. Here, the authors report a simple and generalizable strategy to reverse the EWT-induced quenching mode into light-up mode, b...

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Autores principales:	Chenxu Yan, Zhiqian Guo, Weijie Chi, Wei Fu, Syed Ali Abbas Abedi, Xiaogang Liu, He Tian, Wei-Hong Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/710a5e3455df4aa7879297e1a15ea013
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spelling	oai:doaj.org-article:710a5e3455df4aa7879297e1a15ea0132021-12-02T16:05:51ZFluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents10.1038/s41467-021-24187-52041-1723https://doaj.org/article/710a5e3455df4aa7879297e1a15ea0132021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24187-5https://doaj.org/toc/2041-1723The electron-withdrawing target (EWT)-induced fluorescence quenching is an unsolved issue in intramolecular charge transfer (ICT) fluorophores that limits their applicability. Here, the authors report a simple and generalizable strategy to reverse the EWT-induced quenching mode into light-up mode, by introducing an indazole building block between the π-bridge and the donor in the ICT scaffold.Chenxu YanZhiqian GuoWeijie ChiWei FuSyed Ali Abbas AbediXiaogang LiuHe TianWei-Hong ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chenxu Yan Zhiqian Guo Weijie Chi Wei Fu Syed Ali Abbas Abedi Xiaogang Liu He Tian Wei-Hong Zhu Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents
description	The electron-withdrawing target (EWT)-induced fluorescence quenching is an unsolved issue in intramolecular charge transfer (ICT) fluorophores that limits their applicability. Here, the authors report a simple and generalizable strategy to reverse the EWT-induced quenching mode into light-up mode, by introducing an indazole building block between the π-bridge and the donor in the ICT scaffold.
format	article
author	Chenxu Yan Zhiqian Guo Weijie Chi Wei Fu Syed Ali Abbas Abedi Xiaogang Liu He Tian Wei-Hong Zhu
author_facet	Chenxu Yan Zhiqian Guo Weijie Chi Wei Fu Syed Ali Abbas Abedi Xiaogang Liu He Tian Wei-Hong Zhu
author_sort	Chenxu Yan
title	Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents
title_short	Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents
title_full	Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents
title_fullStr	Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents
title_full_unstemmed	Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents
title_sort	fluorescence umpolung enables light-up sensing of n-acetyltransferases and nerve agents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/710a5e3455df4aa7879297e1a15ea013
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Fluorescence umpolung enables light-up sensing of N-acetyltransferases and nerve agents

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