Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review

Calcific uremic arteriolopathy, commonly referred to as “calciphylaxis,” is a rare life-threatening condition observed in patients with chronic kidney disease and end-stage renal disease on dialysis. This results in necrotic, ischemic, tender dermal lesions anywhere in the body, but mainly on the ab...

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Autores principales:	Sasmit Roy MD, Sohil Narasimha Reddy MD, Amarinder Singh Garcha MD, Praveena Vantipalli MD, Sumit S Patel MD, Ebad Ur Rahman MD, Sreedhar Adapa MD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920 Pathology RB1-214
Acceso en línea:	https://doaj.org/article/710b30f9aa664a539627c0e541364121
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spelling	oai:doaj.org-article:710b30f9aa664a539627c0e5413641212021-12-01T02:03:31ZSuccessful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review2324-709610.1177/23247096211060580https://doaj.org/article/710b30f9aa664a539627c0e5413641212021-11-01T00:00:00Zhttps://doi.org/10.1177/23247096211060580https://doaj.org/toc/2324-7096Calcific uremic arteriolopathy, commonly referred to as “calciphylaxis,” is a rare life-threatening condition observed in patients with chronic kidney disease and end-stage renal disease on dialysis. This results in necrotic, ischemic, tender dermal lesions anywhere in the body, but mainly on the abdominal wall and lower extremities, where subcutaneous tissue is abundant. Histologically, it is defined by calcification in dermal capillaries, arterioles, and subcutaneous adipose tissues. It can occur in all advanced stages of chronic kidney disease as well as end-stage renal disease patients on hemodialysis or peritoneal dialysis. Our case highlights a successful case of calciphylaxis in a young female patient who underwent parathyroidectomy and intensification of peritoneal dialysis regimen along with the infusion of sodium thiosulphate injection resulting in complete resolution of the lesion in 3 months. With limited evidence of treatment options and increased frequency of this condition in a dialysis patient, our case highlights the key aspects of calciphylaxis management in a young end-stage renal disease patient who didn’t need a change of dialysis modality. We also review the risk factors and current practiced management options of this condition in our article.Sasmit Roy MDSohil Narasimha Reddy MDAmarinder Singh Garcha MDPraveena Vantipalli MDSumit S Patel MDEbad Ur Rahman MDSreedhar Adapa MDSAGE PublishingarticleMedicine (General)R5-920PathologyRB1-214ENJournal of Investigative Medicine High Impact Case Reports, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920 Pathology RB1-214
spellingShingle	Medicine (General) R5-920 Pathology RB1-214 Sasmit Roy MD Sohil Narasimha Reddy MD Amarinder Singh Garcha MD Praveena Vantipalli MD Sumit S Patel MD Ebad Ur Rahman MD Sreedhar Adapa MD Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review
description	Calcific uremic arteriolopathy, commonly referred to as “calciphylaxis,” is a rare life-threatening condition observed in patients with chronic kidney disease and end-stage renal disease on dialysis. This results in necrotic, ischemic, tender dermal lesions anywhere in the body, but mainly on the abdominal wall and lower extremities, where subcutaneous tissue is abundant. Histologically, it is defined by calcification in dermal capillaries, arterioles, and subcutaneous adipose tissues. It can occur in all advanced stages of chronic kidney disease as well as end-stage renal disease patients on hemodialysis or peritoneal dialysis. Our case highlights a successful case of calciphylaxis in a young female patient who underwent parathyroidectomy and intensification of peritoneal dialysis regimen along with the infusion of sodium thiosulphate injection resulting in complete resolution of the lesion in 3 months. With limited evidence of treatment options and increased frequency of this condition in a dialysis patient, our case highlights the key aspects of calciphylaxis management in a young end-stage renal disease patient who didn’t need a change of dialysis modality. We also review the risk factors and current practiced management options of this condition in our article.
format	article
author	Sasmit Roy MD Sohil Narasimha Reddy MD Amarinder Singh Garcha MD Praveena Vantipalli MD Sumit S Patel MD Ebad Ur Rahman MD Sreedhar Adapa MD
author_facet	Sasmit Roy MD Sohil Narasimha Reddy MD Amarinder Singh Garcha MD Praveena Vantipalli MD Sumit S Patel MD Ebad Ur Rahman MD Sreedhar Adapa MD
author_sort	Sasmit Roy MD
title	Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review
title_short	Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review
title_full	Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review
title_fullStr	Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review
title_full_unstemmed	Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review
title_sort	successful treatment of calciphylaxis in a young female with end-stage renal disease on peritoneal dialysis with parathyroidectomy, intensification of dialysis, and sodium thiosulphate—a case report and literature review
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/710b30f9aa664a539627c0e541364121
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Successful Treatment of Calciphylaxis in a Young Female With End-Stage Renal Disease on Peritoneal Dialysis With Parathyroidectomy, Intensification of Dialysis, and Sodium Thiosulphate—A Case Report and Literature Review

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