Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults

Cardiovascular disease (CVD) is associated with a higher risk of developing dementia. Studies have found that vascular risk factors are associated with greater amyloid-β (Aβ) and tau burden, which are hallmark neuropathologies of Alzheimer's disease (AD). Evidence for these associations during...

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Autores principales:	Murat Bilgel, Alisa Bannerjee, Andrea Shafer, Yang An, Susan M. Resnick
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cardiovascular diseases Tau Amyloid Temporal lobe Positron emission tomography Aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/710f0d2757b5421a969deedcf148207f
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spelling	oai:doaj.org-article:710f0d2757b5421a969deedcf148207f2021-12-02T05:04:30ZVascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults2666-956010.1016/j.ynirp.2021.100068https://doaj.org/article/710f0d2757b5421a969deedcf148207f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666956021000660https://doaj.org/toc/2666-9560Cardiovascular disease (CVD) is associated with a higher risk of developing dementia. Studies have found that vascular risk factors are associated with greater amyloid-β (Aβ) and tau burden, which are hallmark neuropathologies of Alzheimer's disease (AD). Evidence for these associations during the preclinical stages of AD, when Aβ and tau pathologies first become detectable, is mixed. Quantifying the effect of vascular risk among cognitively normal individuals can help focus the efforts to develop therapeutic approaches aimed at modifying the course of preclinical AD.Using Bayesian analysis, we examined the relationship of Aβ and tau pathology with concurrent vascular risk among 87 cognitively normal individuals (median age 77, interquartile range 70–83) in the Baltimore Longitudinal Study of Aging. We quantified vascular risk as the probability of developing CVD within 10 years using published equations from the Framingham Heart Study. Aβ and tau pathologies were measured using positron emission tomography.As expected, Aβ positive participants had greater tau in the entorhinal cortex (EC) and inferior temporal gyrus (ITG) (difference in means = 0.09, p < 0.05 for each region), and 10-year CVD risk was positively correlated with white matter lesion burden (r = 0.24, p = 0.03). However, we did not find any associations between CVD risk and Aβ or tau. The data provided over two- and four-fold evidence towards the lack of a correlation between CVD risk and tau in the EC (Bayes factor BF = 2.4) and ITG (BF = 4.0), respectively. We found over three-fold evidence towards the lack of a difference in mean CVD risk by Aβ group (BF = 3.4). These null findings were replicated using a data-driven vascular risk score in the BLSA based on a principal component analysis of eight indicators of vascular health.Our data provide moderate evidence towards the lack of an association between vascular risk and concurrent AD neuropathology among cognitively normal older adults. This finding suggests that vascular risk and AD neuropathology may constitute independent pathways in the development of cognitive impairment and dementia.Murat BilgelAlisa BannerjeeAndrea ShaferYang AnSusan M. ResnickElsevierarticleCardiovascular diseasesTauAmyloidTemporal lobePositron emission tomographyAgingNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroimage: Reports, Vol 1, Iss 4, Pp 100068- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cardiovascular diseases Tau Amyloid Temporal lobe Positron emission tomography Aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Cardiovascular diseases Tau Amyloid Temporal lobe Positron emission tomography Aging Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Murat Bilgel Alisa Bannerjee Andrea Shafer Yang An Susan M. Resnick Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults
description	Cardiovascular disease (CVD) is associated with a higher risk of developing dementia. Studies have found that vascular risk factors are associated with greater amyloid-β (Aβ) and tau burden, which are hallmark neuropathologies of Alzheimer's disease (AD). Evidence for these associations during the preclinical stages of AD, when Aβ and tau pathologies first become detectable, is mixed. Quantifying the effect of vascular risk among cognitively normal individuals can help focus the efforts to develop therapeutic approaches aimed at modifying the course of preclinical AD.Using Bayesian analysis, we examined the relationship of Aβ and tau pathology with concurrent vascular risk among 87 cognitively normal individuals (median age 77, interquartile range 70–83) in the Baltimore Longitudinal Study of Aging. We quantified vascular risk as the probability of developing CVD within 10 years using published equations from the Framingham Heart Study. Aβ and tau pathologies were measured using positron emission tomography.As expected, Aβ positive participants had greater tau in the entorhinal cortex (EC) and inferior temporal gyrus (ITG) (difference in means = 0.09, p < 0.05 for each region), and 10-year CVD risk was positively correlated with white matter lesion burden (r = 0.24, p = 0.03). However, we did not find any associations between CVD risk and Aβ or tau. The data provided over two- and four-fold evidence towards the lack of a correlation between CVD risk and tau in the EC (Bayes factor BF = 2.4) and ITG (BF = 4.0), respectively. We found over three-fold evidence towards the lack of a difference in mean CVD risk by Aβ group (BF = 3.4). These null findings were replicated using a data-driven vascular risk score in the BLSA based on a principal component analysis of eight indicators of vascular health.Our data provide moderate evidence towards the lack of an association between vascular risk and concurrent AD neuropathology among cognitively normal older adults. This finding suggests that vascular risk and AD neuropathology may constitute independent pathways in the development of cognitive impairment and dementia.
format	article
author	Murat Bilgel Alisa Bannerjee Andrea Shafer Yang An Susan M. Resnick
author_facet	Murat Bilgel Alisa Bannerjee Andrea Shafer Yang An Susan M. Resnick
author_sort	Murat Bilgel
title	Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults
title_short	Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults
title_full	Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults
title_fullStr	Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults
title_full_unstemmed	Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults
title_sort	vascular risk is not associated with pet measures of alzheimer's disease neuropathology among cognitively normal older adults
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/710f0d2757b5421a969deedcf148207f
work_keys_str_mv	AT muratbilgel vascularriskisnotassociatedwithpetmeasuresofalzheimersdiseaseneuropathologyamongcognitivelynormalolderadults AT alisabannerjee vascularriskisnotassociatedwithpetmeasuresofalzheimersdiseaseneuropathologyamongcognitivelynormalolderadults AT andreashafer vascularriskisnotassociatedwithpetmeasuresofalzheimersdiseaseneuropathologyamongcognitivelynormalolderadults AT yangan vascularriskisnotassociatedwithpetmeasuresofalzheimersdiseaseneuropathologyamongcognitivelynormalolderadults AT susanmresnick vascularriskisnotassociatedwithpetmeasuresofalzheimersdiseaseneuropathologyamongcognitivelynormalolderadults
_version_	1718400657341284352

Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults

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