CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1

Abstract. The changes of cytokine profile revealed in viral influenza-associated pneumonia (A/H1N1) were shown to exceed appropriate parameters for the cases of bacterial outpatient pneumonia. The most expressed hyperproduction of proinflammatory cytokines (IFNγ, TNFα), and a marker of pathological...

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Autores principales:	E. N. Romanova, A. V. Govorin, V. V. Gorbunov, S. A. Lukyanov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	influenza a (h1n1) pneumonia cytokines intercellular adhesion molecules Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/71105d1f0b87496f9d745ff13199df81
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spelling	oai:doaj.org-article:71105d1f0b87496f9d745ff13199df812021-11-18T08:03:40ZCYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N11563-06252313-741X10.15789/1563-0625-2012-1-2-153-156https://doaj.org/article/71105d1f0b87496f9d745ff13199df812014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/321https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The changes of cytokine profile revealed in viral influenza-associated pneumonia (A/H1N1) were shown to exceed appropriate parameters for the cases of bacterial outpatient pneumonia. The most expressed hyperproduction of proinflammatory cytokines (IFNγ, TNFα), and a marker of pathological endothelial activation (sICAM-1) was registered in more severe cases, including those with ALI/ARDS, thus confirming a prognostic value of these parameters. An increased level of IL-10 and decreased IFNγ and TNFα concentrations in the non-severe flu-like pneumonia are indicative for a more balanced immune response. Increased IFNγ concentrations at six months after influenza-associated pneumonia (A/H1N1) may be caused by prolonged use of interferon inducers, as well as persistent antiviral immunity.E. N. RomanovaA. V. GovorinV. V. GorbunovS. A. LukyanovSPb RAACIarticleinfluenza a (h1n1)pneumoniacytokinesintercellular adhesion moleculesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 153-156 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza a (h1n1) pneumonia cytokines intercellular adhesion molecules Immunologic diseases. Allergy RC581-607
spellingShingle	influenza a (h1n1) pneumonia cytokines intercellular adhesion molecules Immunologic diseases. Allergy RC581-607 E. N. Romanova A. V. Govorin V. V. Gorbunov S. A. Lukyanov CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1
description	Abstract. The changes of cytokine profile revealed in viral influenza-associated pneumonia (A/H1N1) were shown to exceed appropriate parameters for the cases of bacterial outpatient pneumonia. The most expressed hyperproduction of proinflammatory cytokines (IFNγ, TNFα), and a marker of pathological endothelial activation (sICAM-1) was registered in more severe cases, including those with ALI/ARDS, thus confirming a prognostic value of these parameters. An increased level of IL-10 and decreased IFNγ and TNFα concentrations in the non-severe flu-like pneumonia are indicative for a more balanced immune response. Increased IFNγ concentrations at six months after influenza-associated pneumonia (A/H1N1) may be caused by prolonged use of interferon inducers, as well as persistent antiviral immunity.
format	article
author	E. N. Romanova A. V. Govorin V. V. Gorbunov S. A. Lukyanov
author_facet	E. N. Romanova A. V. Govorin V. V. Gorbunov S. A. Lukyanov
author_sort	E. N. Romanova
title	CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1
title_short	CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1
title_full	CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1
title_fullStr	CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1
title_full_unstemmed	CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1
title_sort	cytokine levels in blood (ifnγ, tnfα, il-10) and intercellular adhesion molecule (sicam-1) in patients with pneumonia influenza a/h1n1
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/71105d1f0b87496f9d745ff13199df81
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_version_	1718422483129860096

CYTOKINE LEVELS IN BLOOD (IFNγ, TNFα, IL-10) AND INTERCELLULAR ADHESION MOLECULE (sICAM-1) IN PATIENTS WITH PNEUMONIA INFLUENZA A/H1N1

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