VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics

Insulin resistance and lower muscle strength in relation to mass are hallmarks of type 2 diabetes. Here, the authors report alterations in muscle stem cells from individuals with type 2 diabetes that may contribute to these phenotypes through VPS39 mediated effects on autophagy and epigenetics.

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Autores principales: Cajsa Davegårdh, Johanna Säll, Anna Benrick, Christa Broholm, Petr Volkov, Alexander Perfilyev, Tora Ida Henriksen, Yanling Wu, Line Hjort, Charlotte Brøns, Ola Hansson, Maria Pedersen, Jens U. Würthner, Klaus Pfeffer, Emma Nilsson, Allan Vaag, Elisabet Stener-Victorin, Karolina Pircs, Camilla Scheele, Charlotte Ling
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Q
Acceso en línea:https://doaj.org/article/7112e41c1e98491c8e3cfe67e2e5bdd8
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spelling oai:doaj.org-article:7112e41c1e98491c8e3cfe67e2e5bdd82021-12-02T13:39:22ZVPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics10.1038/s41467-021-22068-52041-1723https://doaj.org/article/7112e41c1e98491c8e3cfe67e2e5bdd82021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22068-5https://doaj.org/toc/2041-1723Insulin resistance and lower muscle strength in relation to mass are hallmarks of type 2 diabetes. Here, the authors report alterations in muscle stem cells from individuals with type 2 diabetes that may contribute to these phenotypes through VPS39 mediated effects on autophagy and epigenetics.Cajsa DavegårdhJohanna SällAnna BenrickChrista BroholmPetr VolkovAlexander PerfilyevTora Ida HenriksenYanling WuLine HjortCharlotte BrønsOla HanssonMaria PedersenJens U. WürthnerKlaus PfefferEmma NilssonAllan VaagElisabet Stener-VictorinKarolina PircsCamilla ScheeleCharlotte LingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Cajsa Davegårdh
Johanna Säll
Anna Benrick
Christa Broholm
Petr Volkov
Alexander Perfilyev
Tora Ida Henriksen
Yanling Wu
Line Hjort
Charlotte Brøns
Ola Hansson
Maria Pedersen
Jens U. Würthner
Klaus Pfeffer
Emma Nilsson
Allan Vaag
Elisabet Stener-Victorin
Karolina Pircs
Camilla Scheele
Charlotte Ling
VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
description Insulin resistance and lower muscle strength in relation to mass are hallmarks of type 2 diabetes. Here, the authors report alterations in muscle stem cells from individuals with type 2 diabetes that may contribute to these phenotypes through VPS39 mediated effects on autophagy and epigenetics.
format article
author Cajsa Davegårdh
Johanna Säll
Anna Benrick
Christa Broholm
Petr Volkov
Alexander Perfilyev
Tora Ida Henriksen
Yanling Wu
Line Hjort
Charlotte Brøns
Ola Hansson
Maria Pedersen
Jens U. Würthner
Klaus Pfeffer
Emma Nilsson
Allan Vaag
Elisabet Stener-Victorin
Karolina Pircs
Camilla Scheele
Charlotte Ling
author_facet Cajsa Davegårdh
Johanna Säll
Anna Benrick
Christa Broholm
Petr Volkov
Alexander Perfilyev
Tora Ida Henriksen
Yanling Wu
Line Hjort
Charlotte Brøns
Ola Hansson
Maria Pedersen
Jens U. Würthner
Klaus Pfeffer
Emma Nilsson
Allan Vaag
Elisabet Stener-Victorin
Karolina Pircs
Camilla Scheele
Charlotte Ling
author_sort Cajsa Davegårdh
title VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
title_short VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
title_full VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
title_fullStr VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
title_full_unstemmed VPS39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
title_sort vps39-deficiency observed in type 2 diabetes impairs muscle stem cell differentiation via altered autophagy and epigenetics
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7112e41c1e98491c8e3cfe67e2e5bdd8
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