Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso
Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed bre...
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De Gruyter
2021
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oai:doaj.org-article:7114d3260cc844129f4e9785dec6afb82021-12-05T14:10:42ZCarriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso2391-541210.1515/biol-2021-0113https://doaj.org/article/7114d3260cc844129f4e9785dec6afb82021-10-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0113https://doaj.org/toc/2391-5412Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01–1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information.Zouré Abdou AzaqueAmegnona Lanyo JospinZongo NayiKiendrebeogo Isabelle TouwendpoulimdéSorgho Pegdwendé AbelZongo Fabienne IngridYonli Albert ThéophaneSombié Herman KarimBambara Aboubacar HierrhumSawadogo Alexis YobiOuedraogo Marie N. L.Traoré LassinaZongo Sidnooma VéroniqueLallogo Doriane TatianaBazié Bapio Valery Jean Télesphore ElviraZohoncon Théodora M.Dijgma Florencia W.Simpore JacquesDe Gruyterarticlebreast cancerhla-drb1*11hla-drb1*12risk factorsburkina fasoBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 1101-1110 (2021) |
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breast cancer hla-drb1*11 hla-drb1*12 risk factors burkina faso Biology (General) QH301-705.5 |
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breast cancer hla-drb1*11 hla-drb1*12 risk factors burkina faso Biology (General) QH301-705.5 Zouré Abdou Azaque Amegnona Lanyo Jospin Zongo Nayi Kiendrebeogo Isabelle Touwendpoulimdé Sorgho Pegdwendé Abel Zongo Fabienne Ingrid Yonli Albert Théophane Sombié Herman Karim Bambara Aboubacar Hierrhum Sawadogo Alexis Yobi Ouedraogo Marie N. L. Traoré Lassina Zongo Sidnooma Véronique Lallogo Doriane Tatiana Bazié Bapio Valery Jean Télesphore Elvira Zohoncon Théodora M. Dijgma Florencia W. Simpore Jacques Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| description |
Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity/overweight (OR = 0.13; 95% CI [0.01–1.14]; and p = 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information. |
| format |
article |
| author |
Zouré Abdou Azaque Amegnona Lanyo Jospin Zongo Nayi Kiendrebeogo Isabelle Touwendpoulimdé Sorgho Pegdwendé Abel Zongo Fabienne Ingrid Yonli Albert Théophane Sombié Herman Karim Bambara Aboubacar Hierrhum Sawadogo Alexis Yobi Ouedraogo Marie N. L. Traoré Lassina Zongo Sidnooma Véronique Lallogo Doriane Tatiana Bazié Bapio Valery Jean Télesphore Elvira Zohoncon Théodora M. Dijgma Florencia W. Simpore Jacques |
| author_facet |
Zouré Abdou Azaque Amegnona Lanyo Jospin Zongo Nayi Kiendrebeogo Isabelle Touwendpoulimdé Sorgho Pegdwendé Abel Zongo Fabienne Ingrid Yonli Albert Théophane Sombié Herman Karim Bambara Aboubacar Hierrhum Sawadogo Alexis Yobi Ouedraogo Marie N. L. Traoré Lassina Zongo Sidnooma Véronique Lallogo Doriane Tatiana Bazié Bapio Valery Jean Télesphore Elvira Zohoncon Théodora M. Dijgma Florencia W. Simpore Jacques |
| author_sort |
Zouré Abdou Azaque |
| title |
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_short |
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_full |
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_fullStr |
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_full_unstemmed |
Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso |
| title_sort |
carriage of hla-drb1*11 and 1*12 alleles and risk factors in patients with breast cancer in burkina faso |
| publisher |
De Gruyter |
| publishDate |
2021 |
| url |
https://doaj.org/article/7114d3260cc844129f4e9785dec6afb8 |
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