Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3

Experimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation...

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Auteurs principaux:	Atsushi Kadowaki, Sachiko Miyake, Ryoko Saga, Asako Chiba, Hideki Mochizuki, Takashi Yamamura
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/71209c17bb16432bb7ba84d38a0646fd
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spelling	oai:doaj.org-article:71209c17bb16432bb7ba84d38a0646fd2021-12-02T17:32:08ZGut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-310.1038/ncomms116392041-1723https://doaj.org/article/71209c17bb16432bb7ba84d38a0646fd2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11639https://doaj.org/toc/2041-1723Experimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation in recipient mice with EAE.Atsushi KadowakiSachiko MiyakeRyoko SagaAsako ChibaHideki MochizukiTakashi YamamuraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Atsushi Kadowaki Sachiko Miyake Ryoko Saga Asako Chiba Hideki Mochizuki Takashi Yamamura Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
description	Experimental autoimmune encephalomyelitis (EAE) involves inflammatory cell infiltration into the central nervous system (CNS) and models the human disease multiple sclerosis. Here the authors show that transferred CD4+ gut intraepithelial lymphocytes can migrate into the CNS and inhibit inflammation in recipient mice with EAE.
format	article
author	Atsushi Kadowaki Sachiko Miyake Ryoko Saga Asako Chiba Hideki Mochizuki Takashi Yamamura
author_facet	Atsushi Kadowaki Sachiko Miyake Ryoko Saga Asako Chiba Hideki Mochizuki Takashi Yamamura
author_sort	Atsushi Kadowaki
title	Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_short	Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_full	Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_fullStr	Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_full_unstemmed	Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3
title_sort	gut environment-induced intraepithelial autoreactive cd4+ t cells suppress central nervous system autoimmunity via lag-3
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/71209c17bb16432bb7ba84d38a0646fd
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Gut environment-induced intraepithelial autoreactive CD4+ T cells suppress central nervous system autoimmunity via LAG-3

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