Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis

Atherosclerosis (AS) is a common vascular disease with great harm. The current study examined the expression pattern of miR-18a-5p in AS patients, and explored its clinical values. 110 AS patients and 68 healthy controls were collected clinically, and the expression pattern of miR-18a-5p in the seru...

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Autores principales:	PingPing Teng MM, Yonglei Liu MM, Meng Zhang MM, Wanli Ji MM
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/7120e47d9d304b3e97b748ea7d041166
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spelling	oai:doaj.org-article:7120e47d9d304b3e97b748ea7d0411662021-12-02T01:33:40ZDiagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis1938-272310.1177/10760296211050642https://doaj.org/article/7120e47d9d304b3e97b748ea7d0411662021-11-01T00:00:00Zhttps://doi.org/10.1177/10760296211050642https://doaj.org/toc/1938-2723Atherosclerosis (AS) is a common vascular disease with great harm. The current study examined the expression pattern of miR-18a-5p in AS patients, and explored its clinical values. 110 AS patients and 68 healthy controls were collected clinically, and the expression pattern of miR-18a-5p in the serum of AS patients was detected using qRT-PCR. All AS patients were followed up for five years to record the adverse cardiovascular events. ROC and Kaplan-Meier (K-M) curve were plotted to assess the diagnostic ability. The multiple Cox regression analysis was performed for independent influencing factors analysis. MiR-18a-5p was at high expression in AS patients, and showed positive correlation with the CIMT value ( r = 0.789, P < .001). ROC curve suggested the high diagnostic value of serum miR-18a-5p for AS, with the AUC of 0.894. The diagnostic specificity and sensitivity were 86.8% and 79.1%, respectively. K-M plot demonstrated that cases with high miR-18a-5p levels were more likely to suffer from cardiovascular events, and it is an independent influence factor for the poor clinical outcome. Serum miR-18a-5p serves as a promising biomarker for AS diagnosis, and is related to the occurrence of adverse cardiovascular events.PingPing Teng MMYonglei Liu MMMeng Zhang MMWanli Ji MMSAGE PublishingarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENClinical and Applied Thrombosis/Hemostasis, Vol 27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 PingPing Teng MM Yonglei Liu MM Meng Zhang MM Wanli Ji MM Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis
description	Atherosclerosis (AS) is a common vascular disease with great harm. The current study examined the expression pattern of miR-18a-5p in AS patients, and explored its clinical values. 110 AS patients and 68 healthy controls were collected clinically, and the expression pattern of miR-18a-5p in the serum of AS patients was detected using qRT-PCR. All AS patients were followed up for five years to record the adverse cardiovascular events. ROC and Kaplan-Meier (K-M) curve were plotted to assess the diagnostic ability. The multiple Cox regression analysis was performed for independent influencing factors analysis. MiR-18a-5p was at high expression in AS patients, and showed positive correlation with the CIMT value ( r = 0.789, P < .001). ROC curve suggested the high diagnostic value of serum miR-18a-5p for AS, with the AUC of 0.894. The diagnostic specificity and sensitivity were 86.8% and 79.1%, respectively. K-M plot demonstrated that cases with high miR-18a-5p levels were more likely to suffer from cardiovascular events, and it is an independent influence factor for the poor clinical outcome. Serum miR-18a-5p serves as a promising biomarker for AS diagnosis, and is related to the occurrence of adverse cardiovascular events.
format	article
author	PingPing Teng MM Yonglei Liu MM Meng Zhang MM Wanli Ji MM
author_facet	PingPing Teng MM Yonglei Liu MM Meng Zhang MM Wanli Ji MM
author_sort	PingPing Teng MM
title	Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis
title_short	Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis
title_full	Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis
title_fullStr	Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis
title_full_unstemmed	Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis
title_sort	diagnostic and prognostic significance of serum mir-18a-5p in patients with atherosclerosis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/7120e47d9d304b3e97b748ea7d041166
work_keys_str_mv	AT pingpingtengmm diagnosticandprognosticsignificanceofserummir18a5pinpatientswithatherosclerosis AT yongleiliumm diagnosticandprognosticsignificanceofserummir18a5pinpatientswithatherosclerosis AT mengzhangmm diagnosticandprognosticsignificanceofserummir18a5pinpatientswithatherosclerosis AT wanlijimm diagnosticandprognosticsignificanceofserummir18a5pinpatientswithatherosclerosis
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Diagnostic and Prognostic Significance of serum miR-18a-5p in Patients with Atherosclerosis

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