The morphological identity of insect dendrites.

Dendrite morphology, a neuron's anatomical fingerprint, is a neuroscientist's asset in unveiling organizational principles in the brain. However, the genetic program encoding the morphological identity of a single dendrite remains a mystery. In order to obtain a formal understanding of den...

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Autores principales:	Hermann Cuntz, Friedrich Forstner, Juergen Haag, Alexander Borst
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/71230d13b813458789ff83df1817bc53
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id	oai:doaj.org-article:71230d13b813458789ff83df1817bc53
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spelling	oai:doaj.org-article:71230d13b813458789ff83df1817bc532021-11-25T05:41:55ZThe morphological identity of insect dendrites.1553-734X1553-735810.1371/journal.pcbi.1000251https://doaj.org/article/71230d13b813458789ff83df1817bc532008-12-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19112481/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Dendrite morphology, a neuron's anatomical fingerprint, is a neuroscientist's asset in unveiling organizational principles in the brain. However, the genetic program encoding the morphological identity of a single dendrite remains a mystery. In order to obtain a formal understanding of dendritic branching, we studied distributions of morphological parameters in a group of four individually identifiable neurons of the fly visual system. We found that parameters relating to the branching topology were similar throughout all cells. Only parameters relating to the area covered by the dendrite were cell type specific. With these areas, artificial dendrites were grown based on optimization principles minimizing the amount of wiring and maximizing synaptic democracy. Although the same branching rule was used for all cells, this yielded dendritic structures virtually indistinguishable from their real counterparts. From these principles we derived a fully-automated model-based neuron reconstruction procedure validating the artificial branching rule. In conclusion, we suggest that the genetic program implementing neuronal branching could be constant in all cells whereas the one responsible for the dendrite spanning field should be cell specific.Hermann CuntzFriedrich ForstnerJuergen HaagAlexander BorstPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 4, Iss 12, p e1000251 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Hermann Cuntz Friedrich Forstner Juergen Haag Alexander Borst The morphological identity of insect dendrites.
description	Dendrite morphology, a neuron's anatomical fingerprint, is a neuroscientist's asset in unveiling organizational principles in the brain. However, the genetic program encoding the morphological identity of a single dendrite remains a mystery. In order to obtain a formal understanding of dendritic branching, we studied distributions of morphological parameters in a group of four individually identifiable neurons of the fly visual system. We found that parameters relating to the branching topology were similar throughout all cells. Only parameters relating to the area covered by the dendrite were cell type specific. With these areas, artificial dendrites were grown based on optimization principles minimizing the amount of wiring and maximizing synaptic democracy. Although the same branching rule was used for all cells, this yielded dendritic structures virtually indistinguishable from their real counterparts. From these principles we derived a fully-automated model-based neuron reconstruction procedure validating the artificial branching rule. In conclusion, we suggest that the genetic program implementing neuronal branching could be constant in all cells whereas the one responsible for the dendrite spanning field should be cell specific.
format	article
author	Hermann Cuntz Friedrich Forstner Juergen Haag Alexander Borst
author_facet	Hermann Cuntz Friedrich Forstner Juergen Haag Alexander Borst
author_sort	Hermann Cuntz
title	The morphological identity of insect dendrites.
title_short	The morphological identity of insect dendrites.
title_full	The morphological identity of insect dendrites.
title_fullStr	The morphological identity of insect dendrites.
title_full_unstemmed	The morphological identity of insect dendrites.
title_sort	morphological identity of insect dendrites.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/71230d13b813458789ff83df1817bc53
work_keys_str_mv	AT hermanncuntz themorphologicalidentityofinsectdendrites AT friedrichforstner themorphologicalidentityofinsectdendrites AT juergenhaag themorphologicalidentityofinsectdendrites AT alexanderborst themorphologicalidentityofinsectdendrites AT hermanncuntz morphologicalidentityofinsectdendrites AT friedrichforstner morphologicalidentityofinsectdendrites AT juergenhaag morphologicalidentityofinsectdendrites AT alexanderborst morphologicalidentityofinsectdendrites
_version_	1718414523845574656

The morphological identity of insect dendrites.

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