Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis

Daoud Al-Badriyeh, Chin Fen Neoh, Kay Stewart, David CM KongCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Victoria, AustraliaAbstract: Fungal keratitis is one of the major causes of ophthalmic mycosis and is difficult to treat. The range of c...

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Autores principales:	Daoud Al-Badriyeh, Chin Fen Neoh, Kay Stewart, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7123238f66ab424298e0d8e7a575695c
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spelling	oai:doaj.org-article:7123238f66ab424298e0d8e7a575695c2021-12-02T01:20:43ZClinical utility of voriconazole eye drops in ophthalmic fungal keratitis1177-54671177-5483https://doaj.org/article/7123238f66ab424298e0d8e7a575695c2010-05-01T00:00:00Zhttp://www.dovepress.com/clinical-utility-of-voriconazole-eye-drops-in-ophthalmic-fungal-kerati-a4350https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Daoud Al-Badriyeh, Chin Fen Neoh, Kay Stewart, David CM KongCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Victoria, AustraliaAbstract: Fungal keratitis is one of the major causes of ophthalmic mycosis and is difficult to treat. The range of common antifungal agents available for fungal keratitis remains inadequate and is generally associated with poor clinical outcomes. Voriconazole is a new generation triazole antifungal agent. Only marketed in systemic formulation and, with broad-spectrum activity and high intraocular penetration, voriconazole has demonstrated effectiveness against fungal keratitis. Systemic voriconazole, however, is not without side effects and is costly. Voriconazole eye drops have been prepared extemporaneously and used for the treatment of ophthalmic fungal keratitis. The current article sought to review the literature for evidence related to the effectiveness and safety of topical voriconazole and its corneal penetration into the aqueous humor of the eye. The voriconazole eye drops used are typically of 1% concentration, well tolerated by the eye, and are stable. Despite existing evidence to suggest that the eye drops are effective in the treatment of fungal keratitis, more studies are needed, especially in relation to using the eye drops as first-line and stand-alone treatment, preparation of higher concentrations, and optimal dosing frequency.Keywords: voriconazole, fungal keratitis, eye drops, corneal penetration Daoud Al-BadriyehChin Fen NeohKay Stewartet alDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2010, Iss default, Pp 391-405 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Daoud Al-Badriyeh Chin Fen Neoh Kay Stewart et al Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis
description	Daoud Al-Badriyeh, Chin Fen Neoh, Kay Stewart, David CM KongCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Victoria, AustraliaAbstract: Fungal keratitis is one of the major causes of ophthalmic mycosis and is difficult to treat. The range of common antifungal agents available for fungal keratitis remains inadequate and is generally associated with poor clinical outcomes. Voriconazole is a new generation triazole antifungal agent. Only marketed in systemic formulation and, with broad-spectrum activity and high intraocular penetration, voriconazole has demonstrated effectiveness against fungal keratitis. Systemic voriconazole, however, is not without side effects and is costly. Voriconazole eye drops have been prepared extemporaneously and used for the treatment of ophthalmic fungal keratitis. The current article sought to review the literature for evidence related to the effectiveness and safety of topical voriconazole and its corneal penetration into the aqueous humor of the eye. The voriconazole eye drops used are typically of 1% concentration, well tolerated by the eye, and are stable. Despite existing evidence to suggest that the eye drops are effective in the treatment of fungal keratitis, more studies are needed, especially in relation to using the eye drops as first-line and stand-alone treatment, preparation of higher concentrations, and optimal dosing frequency.Keywords: voriconazole, fungal keratitis, eye drops, corneal penetration
format	article
author	Daoud Al-Badriyeh Chin Fen Neoh Kay Stewart et al
author_facet	Daoud Al-Badriyeh Chin Fen Neoh Kay Stewart et al
author_sort	Daoud Al-Badriyeh
title	Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis
title_short	Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis
title_full	Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis
title_fullStr	Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis
title_full_unstemmed	Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis
title_sort	clinical utility of voriconazole eye drops in ophthalmic fungal keratitis
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/7123238f66ab424298e0d8e7a575695c
work_keys_str_mv	AT daoudalbadriyeh clinicalutilityofvoriconazoleeyedropsinophthalmicfungalkeratitis AT chinfenneoh clinicalutilityofvoriconazoleeyedropsinophthalmicfungalkeratitis AT kaystewart clinicalutilityofvoriconazoleeyedropsinophthalmicfungalkeratitis AT etal clinicalutilityofvoriconazoleeyedropsinophthalmicfungalkeratitis
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Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis

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