Global distribution of sporadic sapovirus infections: A systematic review and meta-analysis.

Acute gastroenteritis (AGE), characterized by diarrhea and vomiting, is an important cause of global mortality, accounting for 9% of all deaths in children under five years of age. Since the reduction of rotavirus in countries that have included rotavirus vaccines in their national immunization prog...

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Autores principales:	Marta Diez Valcarce, Anita K Kambhampati, Laura E Calderwood, Aron J Hall, Sara A Mirza, Jan Vinjé
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71248a11c8aa4a6993021916a11e49af
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spelling	oai:doaj.org-article:71248a11c8aa4a6993021916a11e49af2021-12-02T20:17:48ZGlobal distribution of sporadic sapovirus infections: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0255436https://doaj.org/article/71248a11c8aa4a6993021916a11e49af2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255436https://doaj.org/toc/1932-6203Acute gastroenteritis (AGE), characterized by diarrhea and vomiting, is an important cause of global mortality, accounting for 9% of all deaths in children under five years of age. Since the reduction of rotavirus in countries that have included rotavirus vaccines in their national immunization programs, other viruses such as norovirus and sapovirus have emerged as more common causes of AGE. Due to widespread use of real-time RT-PCR testing, sapovirus has been increasingly reported as the etiologic agent in both AGE outbreaks and sporadic AGE cases. We aimed to assess the role of sapovirus as a cause of endemic AGE worldwide by conducting a systematic review of published studies that used molecular diagnostics to assess the prevalence of sapovirus among individuals with AGE symptoms. Of 106 articles included, the pooled sapovirus prevalence was 3.4%, with highest prevalence among children <5 years of age (4.4%) and among individuals in community settings (7.1%). Compared to studies that used conventional RT-PCR, RT-qPCR assays had a higher pooled prevalence (5.6%). Among individuals without AGE symptoms, the pooled sapovirus prevalence was 2.7%. These results highlight the relative contribution of sapovirus to cases of AGE, especially in community settings and among children <5 years of age.Marta Diez ValcarceAnita K KambhampatiLaura E CalderwoodAron J HallSara A MirzaJan VinjéPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255436 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marta Diez Valcarce Anita K Kambhampati Laura E Calderwood Aron J Hall Sara A Mirza Jan Vinjé Global distribution of sporadic sapovirus infections: A systematic review and meta-analysis.
description	Acute gastroenteritis (AGE), characterized by diarrhea and vomiting, is an important cause of global mortality, accounting for 9% of all deaths in children under five years of age. Since the reduction of rotavirus in countries that have included rotavirus vaccines in their national immunization programs, other viruses such as norovirus and sapovirus have emerged as more common causes of AGE. Due to widespread use of real-time RT-PCR testing, sapovirus has been increasingly reported as the etiologic agent in both AGE outbreaks and sporadic AGE cases. We aimed to assess the role of sapovirus as a cause of endemic AGE worldwide by conducting a systematic review of published studies that used molecular diagnostics to assess the prevalence of sapovirus among individuals with AGE symptoms. Of 106 articles included, the pooled sapovirus prevalence was 3.4%, with highest prevalence among children <5 years of age (4.4%) and among individuals in community settings (7.1%). Compared to studies that used conventional RT-PCR, RT-qPCR assays had a higher pooled prevalence (5.6%). Among individuals without AGE symptoms, the pooled sapovirus prevalence was 2.7%. These results highlight the relative contribution of sapovirus to cases of AGE, especially in community settings and among children <5 years of age.
format	article
author	Marta Diez Valcarce Anita K Kambhampati Laura E Calderwood Aron J Hall Sara A Mirza Jan Vinjé
author_facet	Marta Diez Valcarce Anita K Kambhampati Laura E Calderwood Aron J Hall Sara A Mirza Jan Vinjé
author_sort	Marta Diez Valcarce
title	Global distribution of sporadic sapovirus infections: A systematic review and meta-analysis.
title_short	Global distribution of sporadic sapovirus infections: A systematic review and meta-analysis.
title_full	Global distribution of sporadic sapovirus infections: A systematic review and meta-analysis.
title_fullStr	Global distribution of sporadic sapovirus infections: A systematic review and meta-analysis.
title_full_unstemmed	Global distribution of sporadic sapovirus infections: A systematic review and meta-analysis.
title_sort	global distribution of sporadic sapovirus infections: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/71248a11c8aa4a6993021916a11e49af
work_keys_str_mv	AT martadiezvalcarce globaldistributionofsporadicsapovirusinfectionsasystematicreviewandmetaanalysis AT anitakkambhampati globaldistributionofsporadicsapovirusinfectionsasystematicreviewandmetaanalysis AT lauraecalderwood globaldistributionofsporadicsapovirusinfectionsasystematicreviewandmetaanalysis AT aronjhall globaldistributionofsporadicsapovirusinfectionsasystematicreviewandmetaanalysis AT saraamirza globaldistributionofsporadicsapovirusinfectionsasystematicreviewandmetaanalysis AT janvinje globaldistributionofsporadicsapovirusinfectionsasystematicreviewandmetaanalysis
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Global distribution of sporadic sapovirus infections: A systematic review and meta-analysis.

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