IE-Map: a novel in-vivo atlas and template of the human inner ear

Abstract Brain atlases and templates are core tools in scientific research with increasing importance also in clinical applications. Advances in neuroimaging now allowed us to expand the atlas domain to the vestibular and auditory organ, the inner ear. In this study, we present IE-Map, an in-vivo te...

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Autores principales:	Seyed-Ahmad Ahmadi, Theresa Marie Raiser, Ria Maxine Rühl, Virginia Lee Flanagin, Peter zu Eulenburg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/71284e3f731844a68c033a41bb0f1383
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spelling	oai:doaj.org-article:71284e3f731844a68c033a41bb0f13832021-12-02T14:11:29ZIE-Map: a novel in-vivo atlas and template of the human inner ear10.1038/s41598-021-82716-02045-2322https://doaj.org/article/71284e3f731844a68c033a41bb0f13832021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82716-0https://doaj.org/toc/2045-2322Abstract Brain atlases and templates are core tools in scientific research with increasing importance also in clinical applications. Advances in neuroimaging now allowed us to expand the atlas domain to the vestibular and auditory organ, the inner ear. In this study, we present IE-Map, an in-vivo template and atlas of the human labyrinth derived from multi-modal high-resolution magnetic resonance imaging (MRI) data, in a fully non-invasive manner without any contrast agent or radiation. We reconstructed a common template from 126 inner ears (63 normal subjects) and annotated it with 94 established landmarks and semi-automatic segmentations of all relevant macroscopic vestibular and auditory substructures. We validated the atlas by comparing MRI templates to a novel CT/micro-CT atlas, which we reconstructed from 21 publicly available post-mortem images of the bony labyrinth. Templates in MRI and micro-CT have a high overlap, and several key anatomical measures of the bony labyrinth in IE-Map are in line with micro-CT literature of the inner ear. A quantitative substructural analysis based on the new template, revealed a correlation of labyrinth parameters with total intracranial volume. No effects of gender or laterality were found. We provide the validated templates, atlas segmentations, surface meshes and landmark annotations as open-access material, to provide neuroscience researchers and clinicians in neurology, neurosurgery, and otorhinolaryngology with a widely applicable tool for computational neuro-otology.Seyed-Ahmad AhmadiTheresa Marie RaiserRia Maxine RühlVirginia Lee FlanaginPeter zu EulenburgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seyed-Ahmad Ahmadi Theresa Marie Raiser Ria Maxine Rühl Virginia Lee Flanagin Peter zu Eulenburg IE-Map: a novel in-vivo atlas and template of the human inner ear
description	Abstract Brain atlases and templates are core tools in scientific research with increasing importance also in clinical applications. Advances in neuroimaging now allowed us to expand the atlas domain to the vestibular and auditory organ, the inner ear. In this study, we present IE-Map, an in-vivo template and atlas of the human labyrinth derived from multi-modal high-resolution magnetic resonance imaging (MRI) data, in a fully non-invasive manner without any contrast agent or radiation. We reconstructed a common template from 126 inner ears (63 normal subjects) and annotated it with 94 established landmarks and semi-automatic segmentations of all relevant macroscopic vestibular and auditory substructures. We validated the atlas by comparing MRI templates to a novel CT/micro-CT atlas, which we reconstructed from 21 publicly available post-mortem images of the bony labyrinth. Templates in MRI and micro-CT have a high overlap, and several key anatomical measures of the bony labyrinth in IE-Map are in line with micro-CT literature of the inner ear. A quantitative substructural analysis based on the new template, revealed a correlation of labyrinth parameters with total intracranial volume. No effects of gender or laterality were found. We provide the validated templates, atlas segmentations, surface meshes and landmark annotations as open-access material, to provide neuroscience researchers and clinicians in neurology, neurosurgery, and otorhinolaryngology with a widely applicable tool for computational neuro-otology.
format	article
author	Seyed-Ahmad Ahmadi Theresa Marie Raiser Ria Maxine Rühl Virginia Lee Flanagin Peter zu Eulenburg
author_facet	Seyed-Ahmad Ahmadi Theresa Marie Raiser Ria Maxine Rühl Virginia Lee Flanagin Peter zu Eulenburg
author_sort	Seyed-Ahmad Ahmadi
title	IE-Map: a novel in-vivo atlas and template of the human inner ear
title_short	IE-Map: a novel in-vivo atlas and template of the human inner ear
title_full	IE-Map: a novel in-vivo atlas and template of the human inner ear
title_fullStr	IE-Map: a novel in-vivo atlas and template of the human inner ear
title_full_unstemmed	IE-Map: a novel in-vivo atlas and template of the human inner ear
title_sort	ie-map: a novel in-vivo atlas and template of the human inner ear
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/71284e3f731844a68c033a41bb0f1383
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IE-Map: a novel in-vivo atlas and template of the human inner ear

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