Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety

Gianluca Besozzi,1 Attilio Di Salvatore,2 Daniele Cardillo,2 Alessandro Finzi,2 Joseph Sajish Pinackatt,2 Andrea Baldi,2 Alessandro Monfardini,2 Valeria Forioli,2 Rino Frisina,3 Barbara Parolini2 1Department of Ophthalmology, Vito Fazzi Hospital, Lecce, Italy; 2Department of Ophthalmology, Sant&...

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Autores principales:	Besozzi G, Di Salvatore A, Cardillo D, Finzi A, Pinackatt JS, Baldi A, Monfardini A, Forioli V, Frisina R, Parolini B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Antibiotics retinal toxicity Cefuroxime Combined surgery Endophthalmitis prevention Intracameral cefuroxime Pars plana vitrectomy Phacoemulsification Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/712a6c9d746546429e0d13572dccd06f
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spelling	oai:doaj.org-article:712a6c9d746546429e0d13572dccd06f2021-12-02T00:09:07ZIntracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety1177-5483https://doaj.org/article/712a6c9d746546429e0d13572dccd06f2018-08-01T00:00:00Zhttps://www.dovepress.com/intracameral-cefuroxime-in-combined-pars-plana-vitrectomy-and-phacoemu-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Gianluca Besozzi,1 Attilio Di Salvatore,2 Daniele Cardillo,2 Alessandro Finzi,2 Joseph Sajish Pinackatt,2 Andrea Baldi,2 Alessandro Monfardini,2 Valeria Forioli,2 Rino Frisina,3 Barbara Parolini2 1Department of Ophthalmology, Vito Fazzi Hospital, Lecce, Italy; 2Department of Ophthalmology, Sant’Anna Clinical Institute, Brescia, Italy; 3Department of Ophthalmology, Padova University Hospital, Padova, Italy Background: Postoperative endophthalmitis is a severe complication after intraocular surgery. The aim of this pilot study was to investigate the safety of intracameral cefuroxime in combined vitrectomy and phacoemulsification for cataract and various vitreoretinal disease.Methods: The charts of 152 patients who underwent combined phacoemulsification, intraocular lens implant and pars plana vitrectomy were reviewed. The final tamponade was chosen among fluid, air, gas or silicone oil, based on the requirement of each single case. Patients were operated on by four different surgeons. At the end of surgery, 1 mg/0.1 mL of intracameral cefuroxime (Aprokam) was administered.Results: The mean follow-up was 6.26±7.78 months (range 1–12). No retinal complication, such as retinal infarction or hemorrhages were observed. No acute macular serous detachment and no new intraretinal cysts were noted, in those patients who received optical coherence tomography within the fifth day after surgery. No endophthalmitis was recorded.Conclusion: Intracameral cefuroxime, at the end of combined phacoemulsification and pars plana vitrectomy, is safe as it has no toxicity on the retina and maybe could be considered effective in endophthalmitis prevention. Due to the relatively small number of patients, further studies are advisable.Summary statement: The standard dose of intracameral cefuroxime at the end of combined phacoemulsification and pars plana vitrectomy has no toxic effects on the retina. This paper/The abstract of this paper was presented at the European Vitreo Retinal Society Conference 2017 as a conference talk with interim findings. The poster’s abstract was not published. Keywords: antibiotics retinal toxicity, cefuroxime, combined surgery, endophthalmitis prevention, intracameral cefuroxime, pars plana vitrectomy, phacoemulsificationBesozzi GDi Salvatore ACardillo DFinzi APinackatt JSBaldi AMonfardini AForioli VFrisina RParolini BDove Medical PressarticleAntibiotics retinal toxicity Cefuroxime Combined surgery Endophthalmitis prevention Intracameral cefuroxime Pars plana vitrectomy PhacoemulsificationOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1567-1570 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antibiotics retinal toxicity Cefuroxime Combined surgery Endophthalmitis prevention Intracameral cefuroxime Pars plana vitrectomy Phacoemulsification Ophthalmology RE1-994
spellingShingle	Antibiotics retinal toxicity Cefuroxime Combined surgery Endophthalmitis prevention Intracameral cefuroxime Pars plana vitrectomy Phacoemulsification Ophthalmology RE1-994 Besozzi G Di Salvatore A Cardillo D Finzi A Pinackatt JS Baldi A Monfardini A Forioli V Frisina R Parolini B Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
description	Gianluca Besozzi,1 Attilio Di Salvatore,2 Daniele Cardillo,2 Alessandro Finzi,2 Joseph Sajish Pinackatt,2 Andrea Baldi,2 Alessandro Monfardini,2 Valeria Forioli,2 Rino Frisina,3 Barbara Parolini2 1Department of Ophthalmology, Vito Fazzi Hospital, Lecce, Italy; 2Department of Ophthalmology, Sant’Anna Clinical Institute, Brescia, Italy; 3Department of Ophthalmology, Padova University Hospital, Padova, Italy Background: Postoperative endophthalmitis is a severe complication after intraocular surgery. The aim of this pilot study was to investigate the safety of intracameral cefuroxime in combined vitrectomy and phacoemulsification for cataract and various vitreoretinal disease.Methods: The charts of 152 patients who underwent combined phacoemulsification, intraocular lens implant and pars plana vitrectomy were reviewed. The final tamponade was chosen among fluid, air, gas or silicone oil, based on the requirement of each single case. Patients were operated on by four different surgeons. At the end of surgery, 1 mg/0.1 mL of intracameral cefuroxime (Aprokam) was administered.Results: The mean follow-up was 6.26±7.78 months (range 1–12). No retinal complication, such as retinal infarction or hemorrhages were observed. No acute macular serous detachment and no new intraretinal cysts were noted, in those patients who received optical coherence tomography within the fifth day after surgery. No endophthalmitis was recorded.Conclusion: Intracameral cefuroxime, at the end of combined phacoemulsification and pars plana vitrectomy, is safe as it has no toxicity on the retina and maybe could be considered effective in endophthalmitis prevention. Due to the relatively small number of patients, further studies are advisable.Summary statement: The standard dose of intracameral cefuroxime at the end of combined phacoemulsification and pars plana vitrectomy has no toxic effects on the retina. This paper/The abstract of this paper was presented at the European Vitreo Retinal Society Conference 2017 as a conference talk with interim findings. The poster’s abstract was not published. Keywords: antibiotics retinal toxicity, cefuroxime, combined surgery, endophthalmitis prevention, intracameral cefuroxime, pars plana vitrectomy, phacoemulsification
format	article
author	Besozzi G Di Salvatore A Cardillo D Finzi A Pinackatt JS Baldi A Monfardini A Forioli V Frisina R Parolini B
author_facet	Besozzi G Di Salvatore A Cardillo D Finzi A Pinackatt JS Baldi A Monfardini A Forioli V Frisina R Parolini B
author_sort	Besozzi G
title	Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_short	Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_full	Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_fullStr	Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_full_unstemmed	Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
title_sort	intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/712a6c9d746546429e0d13572dccd06f
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Intracameral cefuroxime in combined pars plana vitrectomy and phacoemulsification: a study of safety

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