Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition

Inhibition and excitation are counterbalanced at synapses, but the conditions that constitute optimal balance are not known. Here the authors show through modelling that the properties of synaptic inhibition are fine-tuned to maintain an optimal balance in which peak excitation reaches precisely to...

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Autores principales:	Jaekyung K. Kim, Christopher D. Fiorillo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/713afc8ca9314d268c56d37b2ccbc709
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spelling	oai:doaj.org-article:713afc8ca9314d268c56d37b2ccbc7092021-12-02T14:40:24ZTheory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition10.1038/ncomms145662041-1723https://doaj.org/article/713afc8ca9314d268c56d37b2ccbc7092017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14566https://doaj.org/toc/2041-1723Inhibition and excitation are counterbalanced at synapses, but the conditions that constitute optimal balance are not known. Here the authors show through modelling that the properties of synaptic inhibition are fine-tuned to maintain an optimal balance in which peak excitation reaches precisely to spike threshold.Jaekyung K. KimChristopher D. FiorilloNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jaekyung K. Kim Christopher D. Fiorillo Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition
description	Inhibition and excitation are counterbalanced at synapses, but the conditions that constitute optimal balance are not known. Here the authors show through modelling that the properties of synaptic inhibition are fine-tuned to maintain an optimal balance in which peak excitation reaches precisely to spike threshold.
format	article
author	Jaekyung K. Kim Christopher D. Fiorillo
author_facet	Jaekyung K. Kim Christopher D. Fiorillo
author_sort	Jaekyung K. Kim
title	Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition
title_short	Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition
title_full	Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition
title_fullStr	Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition
title_full_unstemmed	Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition
title_sort	theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/713afc8ca9314d268c56d37b2ccbc709
work_keys_str_mv	AT jaekyungkkim theoryofoptimalbalancepredictsandexplainstheamplitudeanddecaytimeofsynapticinhibition AT christopherdfiorillo theoryofoptimalbalancepredictsandexplainstheamplitudeanddecaytimeofsynapticinhibition
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Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition

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