SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME

Abstract. Blood serum levels of cytokines (Il-1β, TNFα, IL-2, IL-4, IL-6, IL-8, IL-10, IL-20, IL-23),  cytokine soluble receptors (SRp55 TNFα, SR IL-6), as well as markers of insulin resistance were studied in  a group of male patients with primary gout. Increased levels of the above cytokines and d...

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Autores principales: N. N. Kushnarenko, A. V. Govorin, P. P. Tereshkov
Formato: article
Lenguaje:RU
Publicado: SPb RAACI 2014
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Acceso en línea:https://doaj.org/article/713e881cd43d4d9ebcbd3e41b0eb95c9
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Sumario:Abstract. Blood serum levels of cytokines (Il-1β, TNFα, IL-2, IL-4, IL-6, IL-8, IL-10, IL-20, IL-23),  cytokine soluble receptors (SRp55 TNFα, SR IL-6), as well as markers of insulin resistance were studied in  a group of male patients with primary gout. Increased levels of the above cytokines and deficiency of soluble  IL-6 receptors in blood serum were most pronounced in gouty patients with insulin resistance syndrome. Close  links were revealed between serum uric acid and insulin contents in gouty patients. Significant correlations were  found between the levels of insulin, some cytokines (IL-4, IL-6, TNFα), and soluble receptors (SRp55 TNFα,  SR IL-6), thus presuming a certain role of impaired cytokine profile for development of insulin resistance  syndrome in such cohort of patients. (Med. Immunol., 2011, vol. 13, N 6, pp 627-630)