SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME

Abstract. Blood serum levels of cytokines (Il-1β, TNFα, IL-2, IL-4, IL-6, IL-8, IL-10, IL-20, IL-23), cytokine soluble receptors (SRp55 TNFα, SR IL-6), as well as markers of insulin resistance were studied in a group of male patients with primary gout. Increased levels of the above cytokines and d...

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Autores principales:	N. N. Kushnarenko, A. V. Govorin, P. P. Tereshkov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	gout cytokines cytokine soluble receptors insulin resistance Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/713e881cd43d4d9ebcbd3e41b0eb95c9
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spelling	oai:doaj.org-article:713e881cd43d4d9ebcbd3e41b0eb95c92021-11-18T08:03:42ZSOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME1563-06252313-741X10.15789/1563-0625-2011-6-627-630https://doaj.org/article/713e881cd43d4d9ebcbd3e41b0eb95c92014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/577https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Blood serum levels of cytokines (Il-1β, TNFα, IL-2, IL-4, IL-6, IL-8, IL-10, IL-20, IL-23), cytokine soluble receptors (SRp55 TNFα, SR IL-6), as well as markers of insulin resistance were studied in a group of male patients with primary gout. Increased levels of the above cytokines and deficiency of soluble IL-6 receptors in blood serum were most pronounced in gouty patients with insulin resistance syndrome. Close links were revealed between serum uric acid and insulin contents in gouty patients. Significant correlations were found between the levels of insulin, some cytokines (IL-4, IL-6, TNFα), and soluble receptors (SRp55 TNFα, SR IL-6), thus presuming a certain role of impaired cytokine profile for development of insulin resistance syndrome in such cohort of patients. (Med. Immunol., 2011, vol. 13, N 6, pp 627-630)N. N. KushnarenkoA. V. GovorinP. P. TereshkovSPb RAACIarticlegoutcytokinescytokine soluble receptorsinsulin resistanceImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 6, Pp 627-630 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	gout cytokines cytokine soluble receptors insulin resistance Immunologic diseases. Allergy RC581-607
spellingShingle	gout cytokines cytokine soluble receptors insulin resistance Immunologic diseases. Allergy RC581-607 N. N. Kushnarenko A. V. Govorin P. P. Tereshkov SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME
description	Abstract. Blood serum levels of cytokines (Il-1β, TNFα, IL-2, IL-4, IL-6, IL-8, IL-10, IL-20, IL-23), cytokine soluble receptors (SRp55 TNFα, SR IL-6), as well as markers of insulin resistance were studied in a group of male patients with primary gout. Increased levels of the above cytokines and deficiency of soluble IL-6 receptors in blood serum were most pronounced in gouty patients with insulin resistance syndrome. Close links were revealed between serum uric acid and insulin contents in gouty patients. Significant correlations were found between the levels of insulin, some cytokines (IL-4, IL-6, TNFα), and soluble receptors (SRp55 TNFα, SR IL-6), thus presuming a certain role of impaired cytokine profile for development of insulin resistance syndrome in such cohort of patients. (Med. Immunol., 2011, vol. 13, N 6, pp 627-630)
format	article
author	N. N. Kushnarenko A. V. Govorin P. P. Tereshkov
author_facet	N. N. Kushnarenko A. V. Govorin P. P. Tereshkov
author_sort	N. N. Kushnarenko
title	SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME
title_short	SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME
title_full	SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME
title_fullStr	SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME
title_full_unstemmed	SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME
title_sort	some features of cytokine profile in patients with gout and insulin resistance syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/713e881cd43d4d9ebcbd3e41b0eb95c9
work_keys_str_mv	AT nnkushnarenko somefeaturesofcytokineprofileinpatientswithgoutandinsulinresistancesyndrome AT avgovorin somefeaturesofcytokineprofileinpatientswithgoutandinsulinresistancesyndrome AT pptereshkov somefeaturesofcytokineprofileinpatientswithgoutandinsulinresistancesyndrome
_version_	1718422483506298880

SOME FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH GOUT AND INSULIN RESISTANCE SYNDROME

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