A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine

Due to their simplicity, speed and low cost, chemical spot tests are increasingly demanded for the presumptive identification of illicit drugs in a variety of contexts such as point-of-care assistance or prosecution of drug trafficking. However, most of the colorimetric reactions used in these tests...

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Autores principales:	Neus Jornet-Martínez, Pilar Campíns-Falcó, Rosa Herráez-Hernández
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	amphetamine colorimetric sensors gold bromide drug analysis illicit drug samples Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/713ea26276c74e7d811373456ad8ef67
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spelling	oai:doaj.org-article:713ea26276c74e7d811373456ad8ef672021-11-11T18:39:27ZA Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine10.3390/molecules262167131420-3049https://doaj.org/article/713ea26276c74e7d811373456ad8ef672021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6713https://doaj.org/toc/1420-3049Due to their simplicity, speed and low cost, chemical spot tests are increasingly demanded for the presumptive identification of illicit drugs in a variety of contexts such as point-of-care assistance or prosecution of drug trafficking. However, most of the colorimetric reactions used in these tests are, at best, drug class selective. Therefore, the development of tests based on chemical reactions with improved discrimination power is of great interest. In this work, we propose a new colorimetric assay for amphetamine (AMP) based on its reaction with solutions of alkaline gold bromide to form an insoluble yellow–orange derivative. The resulting suspensions are then filtered onto nylon membranes and the precipitate collected is used for the visual identification of AMP. The measurement of the absorbance of the membranes by diffuse reflectance spectroscopy also allows the quantification of AMP in a simple and rapid way, as demonstrated for different synthetic and drug street samples. On the basis of the results obtained, it was concluded that the proposed procedure is highly selective towards AMP, as this compound could be easily differentiated from other common drugs such as methamphetamine (MET), ephedrine (EPH), scopolamine (SCP) and cocaine (COC).Neus Jornet-MartínezPilar Campíns-FalcóRosa Herráez-HernándezMDPI AGarticleamphetaminecolorimetric sensorsgold bromidedrug analysisillicit drug samplesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6713, p 6713 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amphetamine colorimetric sensors gold bromide drug analysis illicit drug samples Organic chemistry QD241-441
spellingShingle	amphetamine colorimetric sensors gold bromide drug analysis illicit drug samples Organic chemistry QD241-441 Neus Jornet-Martínez Pilar Campíns-Falcó Rosa Herráez-Hernández A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine
description	Due to their simplicity, speed and low cost, chemical spot tests are increasingly demanded for the presumptive identification of illicit drugs in a variety of contexts such as point-of-care assistance or prosecution of drug trafficking. However, most of the colorimetric reactions used in these tests are, at best, drug class selective. Therefore, the development of tests based on chemical reactions with improved discrimination power is of great interest. In this work, we propose a new colorimetric assay for amphetamine (AMP) based on its reaction with solutions of alkaline gold bromide to form an insoluble yellow–orange derivative. The resulting suspensions are then filtered onto nylon membranes and the precipitate collected is used for the visual identification of AMP. The measurement of the absorbance of the membranes by diffuse reflectance spectroscopy also allows the quantification of AMP in a simple and rapid way, as demonstrated for different synthetic and drug street samples. On the basis of the results obtained, it was concluded that the proposed procedure is highly selective towards AMP, as this compound could be easily differentiated from other common drugs such as methamphetamine (MET), ephedrine (EPH), scopolamine (SCP) and cocaine (COC).
format	article
author	Neus Jornet-Martínez Pilar Campíns-Falcó Rosa Herráez-Hernández
author_facet	Neus Jornet-Martínez Pilar Campíns-Falcó Rosa Herráez-Hernández
author_sort	Neus Jornet-Martínez
title	A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine
title_short	A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine
title_full	A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine
title_fullStr	A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine
title_full_unstemmed	A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine
title_sort	colorimetric membrane-based sensor with improved selectivity towards amphetamine
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/713ea26276c74e7d811373456ad8ef67
work_keys_str_mv	AT neusjornetmartinez acolorimetricmembranebasedsensorwithimprovedselectivitytowardsamphetamine AT pilarcampinsfalco acolorimetricmembranebasedsensorwithimprovedselectivitytowardsamphetamine AT rosaherraezhernandez acolorimetricmembranebasedsensorwithimprovedselectivitytowardsamphetamine AT neusjornetmartinez colorimetricmembranebasedsensorwithimprovedselectivitytowardsamphetamine AT pilarcampinsfalco colorimetricmembranebasedsensorwithimprovedselectivitytowardsamphetamine AT rosaherraezhernandez colorimetricmembranebasedsensorwithimprovedselectivitytowardsamphetamine
_version_	1718431768109907968

A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine

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