Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases

Tsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribo...

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Autores principales:	Urszula M. McCaughan, Uma Jayachandran, Vadim Shchepachev, Zhuo Angel Chen, Juri Rappsilber, David Tollervey, Atlanta G. Cook
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/71478f9399644dc58a00d02238d1c896
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spelling	oai:doaj.org-article:71478f9399644dc58a00d02238d1c8962021-12-02T17:31:19ZPre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases10.1038/ncomms117892041-1723https://doaj.org/article/71478f9399644dc58a00d02238d1c8962016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11789https://doaj.org/toc/2041-1723Tsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribosomal maturation to be drawn.Urszula M. McCaughanUma JayachandranVadim ShchepachevZhuo Angel ChenJuri RappsilberDavid TollerveyAtlanta G. CookNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Urszula M. McCaughan Uma Jayachandran Vadim Shchepachev Zhuo Angel Chen Juri Rappsilber David Tollervey Atlanta G. Cook Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases
description	Tsr1 is an essential ribosome biogenesis factor that has known similarity to GTPases. Here, the authors report the Tsr1 crystal structure and show that it is similar to GTPases but that active site residues are not conserved; modelling of the structure into the pre-40S maps allows inferences on ribosomal maturation to be drawn.
format	article
author	Urszula M. McCaughan Uma Jayachandran Vadim Shchepachev Zhuo Angel Chen Juri Rappsilber David Tollervey Atlanta G. Cook
author_facet	Urszula M. McCaughan Uma Jayachandran Vadim Shchepachev Zhuo Angel Chen Juri Rappsilber David Tollervey Atlanta G. Cook
author_sort	Urszula M. McCaughan
title	Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases
title_short	Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases
title_full	Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases
title_fullStr	Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases
title_full_unstemmed	Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases
title_sort	pre-40s ribosome biogenesis factor tsr1 is an inactive structural mimic of translational gtpases
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/71478f9399644dc58a00d02238d1c896
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Pre-40S ribosome biogenesis factor Tsr1 is an inactive structural mimic of translational GTPases

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