Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine

Salih Coskun,1 Sefer Varol,2 Hasan H Ozdemir,2 Elif Agacayak,3 Birsen Aydın,4 Oktay Kapan,5 Mehmet Akif Camkurt,6 Saban Tunc,7 Mehmet Ugur Cevik2 1Department of Medical Genetics, 2Department of Neurology, 3Department of Obstetrics and Gynecology, Medical Faculty, Dicle University, Diyarbakır, Turke...

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Autores principales:	Coskun S, Varol S, Ozdemir HH, Agacayak E, Aydın B, Kapan O, Camkurt MA, Tunc S, Cevik MU
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Migraine Brain-derived neurotrophic factor Nerve growth factor Polymorphism Aura Migraine with aura Headache Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7148b6d57c7d4ad98de5810d62211681
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spelling	oai:doaj.org-article:7148b6d57c7d4ad98de5810d622116812021-12-02T00:22:34ZAssociation of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine1178-2021https://doaj.org/article/7148b6d57c7d4ad98de5810d622116812016-07-01T00:00:00Zhttps://www.dovepress.com/association-of-brain-derived-neurotrophic-factor-and-nerve-growth-fact-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Salih Coskun,1 Sefer Varol,2 Hasan H Ozdemir,2 Elif Agacayak,3 Birsen Aydın,4 Oktay Kapan,5 Mehmet Akif Camkurt,6 Saban Tunc,7 Mehmet Ugur Cevik2 1Department of Medical Genetics, 2Department of Neurology, 3Department of Obstetrics and Gynecology, Medical Faculty, Dicle University, Diyarbakır, Turkey; 4Department of Neurology, Diyarbakır Education and Research Hospital, Diyarbakır, Turkey; 5Department of Neurology, Elaziğ Education and Research Hospital, Elaziğ, Turkey; 6Department of Psychiatry, Afsin State Hospital, Kahramanmaras, Turkey; 7Laboratory of Molecular Genetics, Medical Faculty, Dicle University, Diyarbakır, Turkey Abstract: Migraine is one of the most common neurological diseases worldwide. Migraine pathophysiology is very complex. Genetic factors play a major role in migraine. Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), play an important role in central nervous system functioning, development, and modulation of pain. This study investigates whether polymorphisms in the BDNF and NGF genes are associated with migraine disease in a Turkish case–control population. Overall, 576 subjects were investigated (288 patients with migraine and 288 healthy controls) for the following polymorphisms: rs6265(G/A), rs8192466(C/T), rs925946(G/T), rs2049046(A/T), and rs12273363(T/C) in the BDNF gene, and rs6330(C/T), rs11466112(C/T), rs11102930(C/A), and rs4839435(G/A) in the NGF gene using 5'-exonuclease allelic discrimination assays. We found no differences in frequency of the analyzed eight polymorphisms between migraine and control groups. However, the frequency of minor A alleles of rs6265 in BDNF gene was borderline significant in the patients compared with the healthy controls (P=0.049; odds ratios [ORs] [95% confidence intervals {CIs}] =0.723 [0.523–0.999]). Moreover, when the migraine patients were divided into two subgroups, migraine with aura (MA) and migraine without aura (MO), the minor TT genotype of rs6330 in NGF was significantly higher in MA patients than in MO patients (P=0.036) or healthy controls (P=0.026), and this disappeared after correction for multiple testing. Also, the rs6330T minor allele was more common in the MA group than in the MO group or controls (P=0.011, ORs [95% CIs] =1.626 [1.117–2.365] or P=0.007, ORs [95% CIs] =1.610 [1.140–2.274], respectively). In conclusion, this is the first clinical study to evaluate the association between BDNF and NGF polymorphisms in migraine patients compared with health controls. Our findings suggest that the NGF rs6330T minor allele might be nominated as a risk factor for developing aura in migraine disease. Our results should be considered as preliminary, and they need to be confirmed by future studies. Keywords: migraine, brain-derived neurotrophic factor, nerve growth factor, polymorphism, aura, migraine with aura, headacheCoskun SVarol SOzdemir HHAgacayak EAydın BKapan OCamkurt MATunc SCevik MUDove Medical PressarticleMigraineBrain-derived neurotrophic factorNerve growth factorPolymorphismAuraMigraine with auraHeadacheNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1779-1785 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Migraine Brain-derived neurotrophic factor Nerve growth factor Polymorphism Aura Migraine with aura Headache Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Migraine Brain-derived neurotrophic factor Nerve growth factor Polymorphism Aura Migraine with aura Headache Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Coskun S Varol S Ozdemir HH Agacayak E Aydın B Kapan O Camkurt MA Tunc S Cevik MU Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine
description	Salih Coskun,1 Sefer Varol,2 Hasan H Ozdemir,2 Elif Agacayak,3 Birsen Aydın,4 Oktay Kapan,5 Mehmet Akif Camkurt,6 Saban Tunc,7 Mehmet Ugur Cevik2 1Department of Medical Genetics, 2Department of Neurology, 3Department of Obstetrics and Gynecology, Medical Faculty, Dicle University, Diyarbakır, Turkey; 4Department of Neurology, Diyarbakır Education and Research Hospital, Diyarbakır, Turkey; 5Department of Neurology, Elaziğ Education and Research Hospital, Elaziğ, Turkey; 6Department of Psychiatry, Afsin State Hospital, Kahramanmaras, Turkey; 7Laboratory of Molecular Genetics, Medical Faculty, Dicle University, Diyarbakır, Turkey Abstract: Migraine is one of the most common neurological diseases worldwide. Migraine pathophysiology is very complex. Genetic factors play a major role in migraine. Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), play an important role in central nervous system functioning, development, and modulation of pain. This study investigates whether polymorphisms in the BDNF and NGF genes are associated with migraine disease in a Turkish case–control population. Overall, 576 subjects were investigated (288 patients with migraine and 288 healthy controls) for the following polymorphisms: rs6265(G/A), rs8192466(C/T), rs925946(G/T), rs2049046(A/T), and rs12273363(T/C) in the BDNF gene, and rs6330(C/T), rs11466112(C/T), rs11102930(C/A), and rs4839435(G/A) in the NGF gene using 5'-exonuclease allelic discrimination assays. We found no differences in frequency of the analyzed eight polymorphisms between migraine and control groups. However, the frequency of minor A alleles of rs6265 in BDNF gene was borderline significant in the patients compared with the healthy controls (P=0.049; odds ratios [ORs] [95% confidence intervals {CIs}] =0.723 [0.523–0.999]). Moreover, when the migraine patients were divided into two subgroups, migraine with aura (MA) and migraine without aura (MO), the minor TT genotype of rs6330 in NGF was significantly higher in MA patients than in MO patients (P=0.036) or healthy controls (P=0.026), and this disappeared after correction for multiple testing. Also, the rs6330T minor allele was more common in the MA group than in the MO group or controls (P=0.011, ORs [95% CIs] =1.626 [1.117–2.365] or P=0.007, ORs [95% CIs] =1.610 [1.140–2.274], respectively). In conclusion, this is the first clinical study to evaluate the association between BDNF and NGF polymorphisms in migraine patients compared with health controls. Our findings suggest that the NGF rs6330T minor allele might be nominated as a risk factor for developing aura in migraine disease. Our results should be considered as preliminary, and they need to be confirmed by future studies. Keywords: migraine, brain-derived neurotrophic factor, nerve growth factor, polymorphism, aura, migraine with aura, headache
format	article
author	Coskun S Varol S Ozdemir HH Agacayak E Aydın B Kapan O Camkurt MA Tunc S Cevik MU
author_facet	Coskun S Varol S Ozdemir HH Agacayak E Aydın B Kapan O Camkurt MA Tunc S Cevik MU
author_sort	Coskun S
title	Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine
title_short	Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine
title_full	Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine
title_fullStr	Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine
title_full_unstemmed	Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine
title_sort	association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/7148b6d57c7d4ad98de5810d62211681
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_version_	1718403808083574784

Association of brain-derived neurotrophic factor and nerve growth factor gene polymorphisms with susceptibility to migraine

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