Biomarkers for Prostate Cancer Diagnosis from Genetic Perspectives

Prostate cancers (PC) are mainly diagnosed by screening prostate-specific antigen (PSA) quantity in the blood or a digital rectal exam (DRE). PC typically does not have symptoms contrary to advanced cancers that are diagnosed due to significant symptoms. Diagnosis of PC is established with the trans...

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Autores principales:	Fatemeh Khatami, Seyed Mohammad Kazem Aghamir, Arash Salmaninejad, Sepideh Shivarani, Mohammad Hatef Khorrami
Formato:	article
Lenguaje:	EN
Publicado:	Urology Research Center 2020
Materias:	prostate cancer diagnosis biomarker Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/714d47fe547047bfbef38dbf0219cf62
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spelling	oai:doaj.org-article:714d47fe547047bfbef38dbf0219cf622021-11-28T10:05:25ZBiomarkers for Prostate Cancer Diagnosis from Genetic Perspectives10.22034/TRU.2020.258970.10532717-042Xhttps://doaj.org/article/714d47fe547047bfbef38dbf0219cf622020-05-01T00:00:00Zhttps://www.transresurology.com/article_120189.htmlhttps://doaj.org/toc/2717-042XProstate cancers (PC) are mainly diagnosed by screening prostate-specific antigen (PSA) quantity in the blood or a digital rectal exam (DRE). PC typically does not have symptoms contrary to advanced cancers that are diagnosed due to significant symptoms. Diagnosis of PC is established with the transrectal ultrasound (TRUS) guided biopsy. Estimation of the free PSA to total PSA (fPSA/tPSA) ratio and Multiparametric-magnetic resonance imaging (mp-MRI) can expand the diagnosis accuracy. Several molecular biomarkers have improved PC diagnosis like Confirm MDx, Prostate Core Mitomic Test (PCMT), TMPRSS2-ERG, The PTEN gene, ProMark, 4K score including, and Circulating Tumor Cells (CTCs). These molecular biomarkers are considered both genetic and epigenetic (DNA methylation) hallmarks of PC. We aim to present an overview of all molecular biomarkers of PC and their implication in improving the management of PC patients.Fatemeh Khatami Seyed Mohammad Kazem Aghamir Arash SalmaninejadSepideh ShivaraniMohammad Hatef KhorramiUrology Research Centerarticleprostate cancerdiagnosisbiomarkerDiseases of the genitourinary system. UrologyRC870-923ENTranslational Research in Urology, Vol 2, Iss 2, Pp 51-58 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer diagnosis biomarker Diseases of the genitourinary system. Urology RC870-923
spellingShingle	prostate cancer diagnosis biomarker Diseases of the genitourinary system. Urology RC870-923 Fatemeh Khatami Seyed Mohammad Kazem Aghamir Arash Salmaninejad Sepideh Shivarani Mohammad Hatef Khorrami Biomarkers for Prostate Cancer Diagnosis from Genetic Perspectives
description	Prostate cancers (PC) are mainly diagnosed by screening prostate-specific antigen (PSA) quantity in the blood or a digital rectal exam (DRE). PC typically does not have symptoms contrary to advanced cancers that are diagnosed due to significant symptoms. Diagnosis of PC is established with the transrectal ultrasound (TRUS) guided biopsy. Estimation of the free PSA to total PSA (fPSA/tPSA) ratio and Multiparametric-magnetic resonance imaging (mp-MRI) can expand the diagnosis accuracy. Several molecular biomarkers have improved PC diagnosis like Confirm MDx, Prostate Core Mitomic Test (PCMT), TMPRSS2-ERG, The PTEN gene, ProMark, 4K score including, and Circulating Tumor Cells (CTCs). These molecular biomarkers are considered both genetic and epigenetic (DNA methylation) hallmarks of PC. We aim to present an overview of all molecular biomarkers of PC and their implication in improving the management of PC patients.
format	article
author	Fatemeh Khatami Seyed Mohammad Kazem Aghamir Arash Salmaninejad Sepideh Shivarani Mohammad Hatef Khorrami
author_facet	Fatemeh Khatami Seyed Mohammad Kazem Aghamir Arash Salmaninejad Sepideh Shivarani Mohammad Hatef Khorrami
author_sort	Fatemeh Khatami
title	Biomarkers for Prostate Cancer Diagnosis from Genetic Perspectives
title_short	Biomarkers for Prostate Cancer Diagnosis from Genetic Perspectives
title_full	Biomarkers for Prostate Cancer Diagnosis from Genetic Perspectives
title_fullStr	Biomarkers for Prostate Cancer Diagnosis from Genetic Perspectives
title_full_unstemmed	Biomarkers for Prostate Cancer Diagnosis from Genetic Perspectives
title_sort	biomarkers for prostate cancer diagnosis from genetic perspectives
publisher	Urology Research Center
publishDate	2020
url	https://doaj.org/article/714d47fe547047bfbef38dbf0219cf62
work_keys_str_mv	AT fatemehkhatami biomarkersforprostatecancerdiagnosisfromgeneticperspectives AT seyedmohammadkazemaghamir biomarkersforprostatecancerdiagnosisfromgeneticperspectives AT arashsalmaninejad biomarkersforprostatecancerdiagnosisfromgeneticperspectives AT sepidehshivarani biomarkersforprostatecancerdiagnosisfromgeneticperspectives AT mohammadhatefkhorrami biomarkersforprostatecancerdiagnosisfromgeneticperspectives
_version_	1718408265817128960

Biomarkers for Prostate Cancer Diagnosis from Genetic Perspectives

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