β-Catenin C-terminal signals suppress p53 and are essential for artery formation

How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and that this function is essential for artery formation...

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Autores principales:	Dario F. Riascos-Bernal, Prameladevi Chinnasamy, Longyue (Lily) Cao, Charlene M. Dunaway, Tomas Valenta, Konrad Basler, Nicholas E. S. Sibinga
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/714f114658344539a951b80874578064
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spelling	oai:doaj.org-article:714f114658344539a951b808745780642021-12-02T15:35:45Zβ-Catenin C-terminal signals suppress p53 and are essential for artery formation10.1038/ncomms123892041-1723https://doaj.org/article/714f114658344539a951b808745780642016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12389https://doaj.org/toc/2041-1723How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and that this function is essential for artery formation.Dario F. Riascos-BernalPrameladevi ChinnasamyLongyue (Lily) CaoCharlene M. DunawayTomas ValentaKonrad BaslerNicholas E. S. SibingaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dario F. Riascos-Bernal Prameladevi Chinnasamy Longyue (Lily) Cao Charlene M. Dunaway Tomas Valenta Konrad Basler Nicholas E. S. Sibinga β-Catenin C-terminal signals suppress p53 and are essential for artery formation
description	How p53 is restrained in arterial maturation during embryonic development is unclear. Here, the authors show that β-catenin C-terminal interactions inhibit CREB binding protein-mediated acetylation and activation of p53 in smooth muscle cells, and that this function is essential for artery formation.
format	article
author	Dario F. Riascos-Bernal Prameladevi Chinnasamy Longyue (Lily) Cao Charlene M. Dunaway Tomas Valenta Konrad Basler Nicholas E. S. Sibinga
author_facet	Dario F. Riascos-Bernal Prameladevi Chinnasamy Longyue (Lily) Cao Charlene M. Dunaway Tomas Valenta Konrad Basler Nicholas E. S. Sibinga
author_sort	Dario F. Riascos-Bernal
title	β-Catenin C-terminal signals suppress p53 and are essential for artery formation
title_short	β-Catenin C-terminal signals suppress p53 and are essential for artery formation
title_full	β-Catenin C-terminal signals suppress p53 and are essential for artery formation
title_fullStr	β-Catenin C-terminal signals suppress p53 and are essential for artery formation
title_full_unstemmed	β-Catenin C-terminal signals suppress p53 and are essential for artery formation
title_sort	β-catenin c-terminal signals suppress p53 and are essential for artery formation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/714f114658344539a951b80874578064
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β-Catenin C-terminal signals suppress p53 and are essential for artery formation

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