Sex differences in the association between basal serum cortisol concentrations and cortical thickness

Background: Basal cortisol concentrations vary between men and women. Likewise, previous findings suggest stress-related cortical thickness alterations. Thus, we aimed at elucidating sex differences in the association between serum cortisol concentrations and cortical thickness. Methods: Data of 259...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Johanna Klinger-König, Stefan Frenzel, Anke Hannemann, Katharina Wittfeld, Robin Bülow, Nele Friedrich, Matthias Nauck, Henry Völzke, Hans J. Grabe
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Serum cortisol Cortical thickness Sex differences HPA Axis HPG Axis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/714f197916a54fdfb5ab79feb3219624
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:714f197916a54fdfb5ab79feb3219624
record_format	dspace
spelling	oai:doaj.org-article:714f197916a54fdfb5ab79feb32196242021-11-06T04:30:13ZSex differences in the association between basal serum cortisol concentrations and cortical thickness2352-289510.1016/j.ynstr.2021.100416https://doaj.org/article/714f197916a54fdfb5ab79feb32196242021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352289521001247https://doaj.org/toc/2352-2895Background: Basal cortisol concentrations vary between men and women. Likewise, previous findings suggest stress-related cortical thickness alterations. Thus, we aimed at elucidating sex differences in the association between serum cortisol concentrations and cortical thickness. Methods: Data of 2594 participants (55.55% male; mean age = 53.55 years ± 13.17 years) of the general population were used to investigate sex differences in basal serum cortisol concentrations and associations of serum cortisol concentrations with global and regional cortical thickness. The validity of the results was tested by including sex hormone concentrations as a biological and childhood maltreatment and depressive symptoms as a psychological confounder. Results: Basal serum cortisol concentrations were higher in men than in women (β = −0.158, t(2575) = -6.852, p = 9.056e-12). Sex differences in serum cortisol concentrations were diminished by including serum concentrations of testosterone, estrone, or estradiol in the models. In men but not in women, serum cortisol concentrations were inversely associated with the global cortical thickness (men: β = −0.064, t(1412) = -3.010, p = .003; women: β = −0.016, t(1131) = -0.607, p = .544). Additionally, these effects were observed in eleven cortical regions after adjusting for multiple testing. The associations were independent of childhood maltreatment and depressive symptoms. Conclusion: Sex differences in serum cortisol concentrations and the association between serum cortisol concentrations and cortical thickness suggest important sex-specific effects of stress on the brain. Future studies should integrate the interaction between the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis in sex-stratified analyses.Johanna Klinger-KönigStefan FrenzelAnke HannemannKatharina WittfeldRobin BülowNele FriedrichMatthias NauckHenry VölzkeHans J. GrabeElsevierarticleSerum cortisolCortical thicknessSex differencesHPA AxisHPG AxisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429Neurophysiology and neuropsychologyQP351-495ENNeurobiology of Stress, Vol 15, Iss , Pp 100416- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Serum cortisol Cortical thickness Sex differences HPA Axis HPG Axis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495
spellingShingle	Serum cortisol Cortical thickness Sex differences HPA Axis HPG Axis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495 Johanna Klinger-König Stefan Frenzel Anke Hannemann Katharina Wittfeld Robin Bülow Nele Friedrich Matthias Nauck Henry Völzke Hans J. Grabe Sex differences in the association between basal serum cortisol concentrations and cortical thickness
description	Background: Basal cortisol concentrations vary between men and women. Likewise, previous findings suggest stress-related cortical thickness alterations. Thus, we aimed at elucidating sex differences in the association between serum cortisol concentrations and cortical thickness. Methods: Data of 2594 participants (55.55% male; mean age = 53.55 years ± 13.17 years) of the general population were used to investigate sex differences in basal serum cortisol concentrations and associations of serum cortisol concentrations with global and regional cortical thickness. The validity of the results was tested by including sex hormone concentrations as a biological and childhood maltreatment and depressive symptoms as a psychological confounder. Results: Basal serum cortisol concentrations were higher in men than in women (β = −0.158, t(2575) = -6.852, p = 9.056e-12). Sex differences in serum cortisol concentrations were diminished by including serum concentrations of testosterone, estrone, or estradiol in the models. In men but not in women, serum cortisol concentrations were inversely associated with the global cortical thickness (men: β = −0.064, t(1412) = -3.010, p = .003; women: β = −0.016, t(1131) = -0.607, p = .544). Additionally, these effects were observed in eleven cortical regions after adjusting for multiple testing. The associations were independent of childhood maltreatment and depressive symptoms. Conclusion: Sex differences in serum cortisol concentrations and the association between serum cortisol concentrations and cortical thickness suggest important sex-specific effects of stress on the brain. Future studies should integrate the interaction between the hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) axis in sex-stratified analyses.
format	article
author	Johanna Klinger-König Stefan Frenzel Anke Hannemann Katharina Wittfeld Robin Bülow Nele Friedrich Matthias Nauck Henry Völzke Hans J. Grabe
author_facet	Johanna Klinger-König Stefan Frenzel Anke Hannemann Katharina Wittfeld Robin Bülow Nele Friedrich Matthias Nauck Henry Völzke Hans J. Grabe
author_sort	Johanna Klinger-König
title	Sex differences in the association between basal serum cortisol concentrations and cortical thickness
title_short	Sex differences in the association between basal serum cortisol concentrations and cortical thickness
title_full	Sex differences in the association between basal serum cortisol concentrations and cortical thickness
title_fullStr	Sex differences in the association between basal serum cortisol concentrations and cortical thickness
title_full_unstemmed	Sex differences in the association between basal serum cortisol concentrations and cortical thickness
title_sort	sex differences in the association between basal serum cortisol concentrations and cortical thickness
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/714f197916a54fdfb5ab79feb3219624
work_keys_str_mv	AT johannaklingerkonig sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness AT stefanfrenzel sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness AT ankehannemann sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness AT katharinawittfeld sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness AT robinbulow sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness AT nelefriedrich sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness AT matthiasnauck sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness AT henryvolzke sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness AT hansjgrabe sexdifferencesintheassociationbetweenbasalserumcortisolconcentrationsandcorticalthickness
_version_	1718443859876249600

Sex differences in the association between basal serum cortisol concentrations and cortical thickness

Ejemplares similares