Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles

Sushma Kalmodia,1,2 Jaidev Harjwani,3 Raguraman Rajeswari,1 Wenrong Yang,2 Colin J Barrow,2 Sundara Ramaprabhu,3 Subramanian Krishnakumar,1,* Sailaja V Elchuri1,* 1Department of Nanobiotechnology, Sankara Nethralaya, Chennai, India; 2Centre for Chemistry and Biotechnology, Deakin University, Geelong...

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Autores principales:	Kalmodia S, Harjwani J, Rajeswari R, Yang W, Barrow CJ, Ramaprabhu S, Krishnakumar S, Elchuri SV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/715893eeaf4d47faadcb9fbbb774f4e9
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spelling	oai:doaj.org-article:715893eeaf4d47faadcb9fbbb774f4e92021-12-02T01:07:59ZSynthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles1176-91141178-2013https://doaj.org/article/715893eeaf4d47faadcb9fbbb774f4e92013-11-01T00:00:00Zhttp://www.dovepress.com/synthesis-and-characterization-of-surface-enhanced-raman-scattered-gol-a14907https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sushma Kalmodia,1,2 Jaidev Harjwani,3 Raguraman Rajeswari,1 Wenrong Yang,2 Colin J Barrow,2 Sundara Ramaprabhu,3 Subramanian Krishnakumar,1,* Sailaja V Elchuri1,* 1Department of Nanobiotechnology, Sankara Nethralaya, Chennai, India; 2Centre for Chemistry and Biotechnology, Deakin University, Geelong, VIC, Australia; 3Alternative Energy and Nanotechnology Lab, Indian Institute of Technology, Madras, India *These authors contributed equally to this work Abstract: In this paper, we report a simple, rapid, and robust method to synthesize surface-enhanced Raman-scattered gold nanoparticles (GNPs) based on green chemistry. Vitis vinifera L. extract was used to synthesize noncytotoxic Raman-active GNPs. These GNPs were characterized by ultraviolet-visible spectroscopy, dynamic light-scattering, Fourier-transform infrared (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Raman spectroscopy. The characteristic surface plasmon-resonance band at ~528 nm is indicative of spherical particles, and this was confirmed by TEM. The N–H and C–O stretches in FTIR spectroscopy indicated the presence of protein molecules. The predominant XRD plane at (111) and (200) indicated the crystalline nature and purity of GNPs. GNPs were stable in the buffers used for biological studies, and exhibited no cytotoxicity in noncancerous MIO-M1 (Müller glial) and MDA-MB-453 (breast cancer) cell lines. The GNPs exhibited Raman spectral peaks at 570, 788, and 1,102 cm-1. These new GNPs have potential applications in cancer diagnosis, therapy, and ultrasensitive biomarker detection. Keywords: GNPs, SERS, SPR, Vitis vinifera L., stabilityKalmodia SHarjwani JRajeswari RYang WBarrow CJRamaprabhu SKrishnakumar SElchuri SVDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss Issue 1, Pp 4327-4338 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kalmodia S Harjwani J Rajeswari R Yang W Barrow CJ Ramaprabhu S Krishnakumar S Elchuri SV Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles
description	Sushma Kalmodia,1,2 Jaidev Harjwani,3 Raguraman Rajeswari,1 Wenrong Yang,2 Colin J Barrow,2 Sundara Ramaprabhu,3 Subramanian Krishnakumar,1,* Sailaja V Elchuri1,* 1Department of Nanobiotechnology, Sankara Nethralaya, Chennai, India; 2Centre for Chemistry and Biotechnology, Deakin University, Geelong, VIC, Australia; 3Alternative Energy and Nanotechnology Lab, Indian Institute of Technology, Madras, India *These authors contributed equally to this work Abstract: In this paper, we report a simple, rapid, and robust method to synthesize surface-enhanced Raman-scattered gold nanoparticles (GNPs) based on green chemistry. Vitis vinifera L. extract was used to synthesize noncytotoxic Raman-active GNPs. These GNPs were characterized by ultraviolet-visible spectroscopy, dynamic light-scattering, Fourier-transform infrared (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Raman spectroscopy. The characteristic surface plasmon-resonance band at ~528 nm is indicative of spherical particles, and this was confirmed by TEM. The N–H and C–O stretches in FTIR spectroscopy indicated the presence of protein molecules. The predominant XRD plane at (111) and (200) indicated the crystalline nature and purity of GNPs. GNPs were stable in the buffers used for biological studies, and exhibited no cytotoxicity in noncancerous MIO-M1 (Müller glial) and MDA-MB-453 (breast cancer) cell lines. The GNPs exhibited Raman spectral peaks at 570, 788, and 1,102 cm-1. These new GNPs have potential applications in cancer diagnosis, therapy, and ultrasensitive biomarker detection. Keywords: GNPs, SERS, SPR, Vitis vinifera L., stability
format	article
author	Kalmodia S Harjwani J Rajeswari R Yang W Barrow CJ Ramaprabhu S Krishnakumar S Elchuri SV
author_facet	Kalmodia S Harjwani J Rajeswari R Yang W Barrow CJ Ramaprabhu S Krishnakumar S Elchuri SV
author_sort	Kalmodia S
title	Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles
title_short	Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles
title_full	Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles
title_fullStr	Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles
title_full_unstemmed	Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles
title_sort	synthesis and characterization of surface-enhanced raman-scattered gold nanoparticles
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/715893eeaf4d47faadcb9fbbb774f4e9
work_keys_str_mv	AT kalmodias synthesisandcharacterizationofsurfaceenhancedramanscatteredgoldnanoparticles AT harjwanij synthesisandcharacterizationofsurfaceenhancedramanscatteredgoldnanoparticles AT rajeswarir synthesisandcharacterizationofsurfaceenhancedramanscatteredgoldnanoparticles AT yangw synthesisandcharacterizationofsurfaceenhancedramanscatteredgoldnanoparticles AT barrowcj synthesisandcharacterizationofsurfaceenhancedramanscatteredgoldnanoparticles AT ramaprabhus synthesisandcharacterizationofsurfaceenhancedramanscatteredgoldnanoparticles AT krishnakumars synthesisandcharacterizationofsurfaceenhancedramanscatteredgoldnanoparticles AT elchurisv synthesisandcharacterizationofsurfaceenhancedramanscatteredgoldnanoparticles
_version_	1718403263229853696

Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles

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