Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug

Hao Wang,1 Wei Gu,2 Ning Xiao,2 Ling Ye,2 Qunyuan Xu1 1Regeneration and Repair, Key Laboratory for Neurodegenerative Disease of The Ministry of Education, 2School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, People's Republic of China Abstract: Curr...

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Autores principales:	Wang H, Gu W, Xiao N, Ye L, Xu Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/715e336e95b542a1a6da5eecad8a55e2
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spelling	oai:doaj.org-article:715e336e95b542a1a6da5eecad8a55e22021-12-02T02:42:30ZChlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug1178-2013https://doaj.org/article/715e336e95b542a1a6da5eecad8a55e22014-03-01T00:00:00Zhttp://www.dovepress.com/chlorotoxin-conjugated-graphene-oxide-for-targeted-delivery-of-an-anti-a16143https://doaj.org/toc/1178-2013 Hao Wang,1 Wei Gu,2 Ning Xiao,2 Ling Ye,2 Qunyuan Xu1 1Regeneration and Repair, Key Laboratory for Neurodegenerative Disease of The Ministry of Education, 2School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, People's Republic of China Abstract: Current chemotherapy for glioma is rarely satisfactory due to low therapeutic efficiency and systemic side effects. We have developed a glioma-targeted drug delivery system based on graphene oxide. Targeted peptide chlorotoxin-conjugated graphene oxide (CTX-GO) sheets were successfully synthesized and characterized. Doxorubicin was loaded onto CTX-GO (CTX-GO/DOX) with high efficiency (570 mg doxorubicin per gram CTX-GO) via noncovalent interactions. Doxorubicin release was pH-dependent and showed sustained-release properties. Cytotoxicity experiments demonstrated that CTX-GO/DOX mediated the highest rate of death of glioma cells compared with free doxorubicin or graphene oxide loaded with doxorubicin only. Further, conjugation with chlorotoxin enhanced accumulation of doxorubicin within glioma cells. These findings indicate that CTX-GO is a promising platform for drug delivery and provide a rationale for developing a glioma-specific drug delivery system. Keywords: glioma, nanosheet, pH-dependent, cytotoxicityWang HGu WXiao NYe LXu QDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 1433-1442 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Wang H Gu W Xiao N Ye L Xu Q Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug
description	Hao Wang,1 Wei Gu,2 Ning Xiao,2 Ling Ye,2 Qunyuan Xu1 1Regeneration and Repair, Key Laboratory for Neurodegenerative Disease of The Ministry of Education, 2School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, People's Republic of China Abstract: Current chemotherapy for glioma is rarely satisfactory due to low therapeutic efficiency and systemic side effects. We have developed a glioma-targeted drug delivery system based on graphene oxide. Targeted peptide chlorotoxin-conjugated graphene oxide (CTX-GO) sheets were successfully synthesized and characterized. Doxorubicin was loaded onto CTX-GO (CTX-GO/DOX) with high efficiency (570 mg doxorubicin per gram CTX-GO) via noncovalent interactions. Doxorubicin release was pH-dependent and showed sustained-release properties. Cytotoxicity experiments demonstrated that CTX-GO/DOX mediated the highest rate of death of glioma cells compared with free doxorubicin or graphene oxide loaded with doxorubicin only. Further, conjugation with chlorotoxin enhanced accumulation of doxorubicin within glioma cells. These findings indicate that CTX-GO is a promising platform for drug delivery and provide a rationale for developing a glioma-specific drug delivery system. Keywords: glioma, nanosheet, pH-dependent, cytotoxicity
format	article
author	Wang H Gu W Xiao N Ye L Xu Q
author_facet	Wang H Gu W Xiao N Ye L Xu Q
author_sort	Wang H
title	Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug
title_short	Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug
title_full	Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug
title_fullStr	Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug
title_full_unstemmed	Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug
title_sort	chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/715e336e95b542a1a6da5eecad8a55e2
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_version_	1718402225878859776

Chlorotoxin-conjugated graphene oxide for targeted delivery of an anticancer drug

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