Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)

Wistar Albino Glaxo Rijswijk (WAG/Rij) rats are widely used in basic and pre-clinical studies as a valid genetic model of absence epilepsy. Adult WAG/Rij rats exhibit generalized 8–10-Hz spike-wave discharges (SWDs) in the electroencephalogram. SWDs are known to result from thalamocortical circuit d...

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Autor principal:	Evgenia Sitnikova
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	spike-wave epilepsy genetic rat model slow wave sleep intermediate stage of sleep microarousals Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/715ee885f4074caf831c1d3a4d6e4899
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spelling	oai:doaj.org-article:715ee885f4074caf831c1d3a4d6e48992021-11-05T07:09:54ZSleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)1664-229510.3389/fneur.2021.766566https://doaj.org/article/715ee885f4074caf831c1d3a4d6e48992021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.766566/fullhttps://doaj.org/toc/1664-2295Wistar Albino Glaxo Rijswijk (WAG/Rij) rats are widely used in basic and pre-clinical studies as a valid genetic model of absence epilepsy. Adult WAG/Rij rats exhibit generalized 8–10-Hz spike-wave discharges (SWDs) in the electroencephalogram. SWDs are known to result from thalamocortical circuit dysfunction, and this implies an intimate relationship between slow-wave EEG activity, sleep spindles, and SWDs. The present mini review summarizes relevant research on sleep-related disturbances associated with spike-wave epilepsy in WAG/Rij rats in the domain of slow-wave sleep EEG and microarousals. It also discusses enhancement of the intermediate stage of sleep. In general, sleep EEG studies provide important information about epileptogenic processes related to spike-wave epilepsy.Evgenia SitnikovaFrontiers Media S.A.articlespike-wave epilepsygenetic rat modelslow wave sleepintermediate stage of sleepmicroarousalsNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spike-wave epilepsy genetic rat model slow wave sleep intermediate stage of sleep microarousals Neurology. Diseases of the nervous system RC346-429
spellingShingle	spike-wave epilepsy genetic rat model slow wave sleep intermediate stage of sleep microarousals Neurology. Diseases of the nervous system RC346-429 Evgenia Sitnikova Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)
description	Wistar Albino Glaxo Rijswijk (WAG/Rij) rats are widely used in basic and pre-clinical studies as a valid genetic model of absence epilepsy. Adult WAG/Rij rats exhibit generalized 8–10-Hz spike-wave discharges (SWDs) in the electroencephalogram. SWDs are known to result from thalamocortical circuit dysfunction, and this implies an intimate relationship between slow-wave EEG activity, sleep spindles, and SWDs. The present mini review summarizes relevant research on sleep-related disturbances associated with spike-wave epilepsy in WAG/Rij rats in the domain of slow-wave sleep EEG and microarousals. It also discusses enhancement of the intermediate stage of sleep. In general, sleep EEG studies provide important information about epileptogenic processes related to spike-wave epilepsy.
format	article
author	Evgenia Sitnikova
author_facet	Evgenia Sitnikova
author_sort	Evgenia Sitnikova
title	Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)
title_short	Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)
title_full	Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)
title_fullStr	Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)
title_full_unstemmed	Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)
title_sort	sleep disturbances in rats with genetic pre-disposition to spike-wave epilepsy (wag/rij)
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/715ee885f4074caf831c1d3a4d6e4899
work_keys_str_mv	AT evgeniasitnikova sleepdisturbancesinratswithgeneticpredispositiontospikewaveepilepsywagrij
_version_	1718444475416576000

Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)

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