miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models

Depletion of the splicing factors MBNL 1 and 2 causes myotonic dystrophy. Here, the authors show that miR-23b and miR-218 target MBNL proteins, and that antagonists to these miRNAs rescue mis-splicing events in myoblasts and boost MBNL expression and rescue pathology in mouse models.

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Autores principales:	Estefania Cerro-Herreros, Maria Sabater-Arcis, Juan M. Fernandez-Costa, Nerea Moreno, Manuel Perez-Alonso, Beatriz Llamusi, Ruben Artero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/715ef215d4ed408da2bed0dd25f82d03
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spelling	oai:doaj.org-article:715ef215d4ed408da2bed0dd25f82d032021-12-02T14:40:05ZmiR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models10.1038/s41467-018-04892-42041-1723https://doaj.org/article/715ef215d4ed408da2bed0dd25f82d032018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04892-4https://doaj.org/toc/2041-1723Depletion of the splicing factors MBNL 1 and 2 causes myotonic dystrophy. Here, the authors show that miR-23b and miR-218 target MBNL proteins, and that antagonists to these miRNAs rescue mis-splicing events in myoblasts and boost MBNL expression and rescue pathology in mouse models.Estefania Cerro-HerrerosMaria Sabater-ArcisJuan M. Fernandez-CostaNerea MorenoManuel Perez-AlonsoBeatriz LlamusiRuben ArteroNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Estefania Cerro-Herreros Maria Sabater-Arcis Juan M. Fernandez-Costa Nerea Moreno Manuel Perez-Alonso Beatriz Llamusi Ruben Artero miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
description	Depletion of the splicing factors MBNL 1 and 2 causes myotonic dystrophy. Here, the authors show that miR-23b and miR-218 target MBNL proteins, and that antagonists to these miRNAs rescue mis-splicing events in myoblasts and boost MBNL expression and rescue pathology in mouse models.
format	article
author	Estefania Cerro-Herreros Maria Sabater-Arcis Juan M. Fernandez-Costa Nerea Moreno Manuel Perez-Alonso Beatriz Llamusi Ruben Artero
author_facet	Estefania Cerro-Herreros Maria Sabater-Arcis Juan M. Fernandez-Costa Nerea Moreno Manuel Perez-Alonso Beatriz Llamusi Ruben Artero
author_sort	Estefania Cerro-Herreros
title	miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
title_short	miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
title_full	miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
title_fullStr	miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
title_full_unstemmed	miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
title_sort	mir-23b and mir-218 silencing increase muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/715ef215d4ed408da2bed0dd25f82d03
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miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models

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