Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes

Possible immunogenicity of the Cas9 protein raises concerns about therapeutic applications. Here the authors identify pre-existing CD8+T-cell immunity in healthy individuals and in response modify Cas9 to remove the immunodominant epitopes.

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Autores principales:	Shayesteh R. Ferdosi, Radwa Ewaisha, Farzaneh Moghadam, Sri Krishna, Jin G. Park, Mo R. Ebrahimkhani, Samira Kiani, Karen S. Anderson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7163fcf8bec84bbaa28f45dd3cb383d7
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spelling	oai:doaj.org-article:7163fcf8bec84bbaa28f45dd3cb383d72021-12-02T15:36:18ZMultifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes10.1038/s41467-019-09693-x2041-1723https://doaj.org/article/7163fcf8bec84bbaa28f45dd3cb383d72019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09693-xhttps://doaj.org/toc/2041-1723Possible immunogenicity of the Cas9 protein raises concerns about therapeutic applications. Here the authors identify pre-existing CD8+T-cell immunity in healthy individuals and in response modify Cas9 to remove the immunodominant epitopes.Shayesteh R. FerdosiRadwa EwaishaFarzaneh MoghadamSri KrishnaJin G. ParkMo R. EbrahimkhaniSamira KianiKaren S. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shayesteh R. Ferdosi Radwa Ewaisha Farzaneh Moghadam Sri Krishna Jin G. Park Mo R. Ebrahimkhani Samira Kiani Karen S. Anderson Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
description	Possible immunogenicity of the Cas9 protein raises concerns about therapeutic applications. Here the authors identify pre-existing CD8+T-cell immunity in healthy individuals and in response modify Cas9 to remove the immunodominant epitopes.
format	article
author	Shayesteh R. Ferdosi Radwa Ewaisha Farzaneh Moghadam Sri Krishna Jin G. Park Mo R. Ebrahimkhani Samira Kiani Karen S. Anderson
author_facet	Shayesteh R. Ferdosi Radwa Ewaisha Farzaneh Moghadam Sri Krishna Jin G. Park Mo R. Ebrahimkhani Samira Kiani Karen S. Anderson
author_sort	Shayesteh R. Ferdosi
title	Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
title_short	Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
title_full	Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
title_fullStr	Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
title_full_unstemmed	Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
title_sort	multifunctional crispr-cas9 with engineered immunosilenced human t cell epitopes
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/7163fcf8bec84bbaa28f45dd3cb383d7
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Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes

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