Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1

Studies imply that cell adhesion geometry during interphase dictates the orientation of the cell division axis. Here the authors show that accumulation of caveolin-1 to rapidly retracting regions during cell rounding sets the spindle orientation by recruiting Gαi1-LGN-NuMA to the cortex.

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Autores principales:	Shigeru Matsumura, Tomoko Kojidani, Yuji Kamioka, Seiichi Uchida, Tokuko Haraguchi, Akatsuki Kimura, Fumiko Toyoshima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/716422a38e6f455ba08b04cf57508852
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spelling	oai:doaj.org-article:716422a38e6f455ba08b04cf575088522021-12-02T16:57:01ZInterphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-110.1038/ncomms118582041-1723https://doaj.org/article/716422a38e6f455ba08b04cf575088522016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11858https://doaj.org/toc/2041-1723Studies imply that cell adhesion geometry during interphase dictates the orientation of the cell division axis. Here the authors show that accumulation of caveolin-1 to rapidly retracting regions during cell rounding sets the spindle orientation by recruiting Gαi1-LGN-NuMA to the cortex.Shigeru MatsumuraTomoko KojidaniYuji KamiokaSeiichi UchidaTokuko HaraguchiAkatsuki KimuraFumiko ToyoshimaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shigeru Matsumura Tomoko Kojidani Yuji Kamioka Seiichi Uchida Tokuko Haraguchi Akatsuki Kimura Fumiko Toyoshima Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1
description	Studies imply that cell adhesion geometry during interphase dictates the orientation of the cell division axis. Here the authors show that accumulation of caveolin-1 to rapidly retracting regions during cell rounding sets the spindle orientation by recruiting Gαi1-LGN-NuMA to the cortex.
format	article
author	Shigeru Matsumura Tomoko Kojidani Yuji Kamioka Seiichi Uchida Tokuko Haraguchi Akatsuki Kimura Fumiko Toyoshima
author_facet	Shigeru Matsumura Tomoko Kojidani Yuji Kamioka Seiichi Uchida Tokuko Haraguchi Akatsuki Kimura Fumiko Toyoshima
author_sort	Shigeru Matsumura
title	Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1
title_short	Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1
title_full	Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1
title_fullStr	Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1
title_full_unstemmed	Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1
title_sort	interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/716422a38e6f455ba08b04cf57508852
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Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1

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