Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia

In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment. During decades, researchers have used engraftment to study the function of adhesion molecules in HS...

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Autores principales:	Julien M. P. Grenier, Céline Testut, Cyril Fauriat, Stéphane J. C. Mancini, Michel Aurrand-Lions
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	adhesion haematopoietic stem cell leukemic stem cell haematopoiesis bone marrow acute myeloid leukaemia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/71651b1cfd9d47078cabce2a3a0be5cf
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spelling	oai:doaj.org-article:71651b1cfd9d47078cabce2a3a0be5cf2021-11-12T06:11:21ZAdhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia1664-322410.3389/fimmu.2021.756231https://doaj.org/article/71651b1cfd9d47078cabce2a3a0be5cf2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.756231/fullhttps://doaj.org/toc/1664-3224In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment. During decades, researchers have used engraftment to study the function of adhesion molecules in HSC’s homeostasis regulation. Since the 90’s, progress in genetically engineered mouse models has allowed a better understanding of adhesion molecules involved in HSCs regulation by BM niches and raised questions about the role of adhesion mechanisms in conferring drug resistance to cancer cells nested in the BM. This has been especially studied in acute myeloid leukaemia (AML) which was the first disease in which the concept of cancer stem cell (CSC) or leukemic stem cells (LSCs) was demonstrated. In AML, it has been proposed that LSCs propagate the disease and are able to replenish the leukemic bulk after complete remission suggesting that LSC may be endowed with drug resistance properties. However, whether such properties are due to extrinsic or intrinsic molecular mechanisms, fully or partially supported by molecular crosstalk between LSCs and surrounding BM micro-environment is still matter of debate. In this review, we focus on adhesion molecules that have been involved in HSCs or LSCs anchoring to BM niches and discuss if inhibition of such mechanism may represent new therapeutic avenues to eradicate LSCs.Julien M. P. GrenierCéline TestutCyril FauriatStéphane J. C. ManciniMichel Aurrand-LionsFrontiers Media S.A.articleadhesionhaematopoietic stem cellleukemic stem cellhaematopoiesisbone marrowacute myeloid leukaemiaImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adhesion haematopoietic stem cell leukemic stem cell haematopoiesis bone marrow acute myeloid leukaemia Immunologic diseases. Allergy RC581-607
spellingShingle	adhesion haematopoietic stem cell leukemic stem cell haematopoiesis bone marrow acute myeloid leukaemia Immunologic diseases. Allergy RC581-607 Julien M. P. Grenier Céline Testut Cyril Fauriat Stéphane J. C. Mancini Michel Aurrand-Lions Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia
description	In the bone marrow (BM) of adult mammals, haematopoietic stem cells (HSCs) are retained in micro-anatomical structures by adhesion molecules that regulate HSC quiescence, proliferation and commitment. During decades, researchers have used engraftment to study the function of adhesion molecules in HSC’s homeostasis regulation. Since the 90’s, progress in genetically engineered mouse models has allowed a better understanding of adhesion molecules involved in HSCs regulation by BM niches and raised questions about the role of adhesion mechanisms in conferring drug resistance to cancer cells nested in the BM. This has been especially studied in acute myeloid leukaemia (AML) which was the first disease in which the concept of cancer stem cell (CSC) or leukemic stem cells (LSCs) was demonstrated. In AML, it has been proposed that LSCs propagate the disease and are able to replenish the leukemic bulk after complete remission suggesting that LSC may be endowed with drug resistance properties. However, whether such properties are due to extrinsic or intrinsic molecular mechanisms, fully or partially supported by molecular crosstalk between LSCs and surrounding BM micro-environment is still matter of debate. In this review, we focus on adhesion molecules that have been involved in HSCs or LSCs anchoring to BM niches and discuss if inhibition of such mechanism may represent new therapeutic avenues to eradicate LSCs.
format	article
author	Julien M. P. Grenier Céline Testut Cyril Fauriat Stéphane J. C. Mancini Michel Aurrand-Lions
author_facet	Julien M. P. Grenier Céline Testut Cyril Fauriat Stéphane J. C. Mancini Michel Aurrand-Lions
author_sort	Julien M. P. Grenier
title	Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia
title_short	Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia
title_full	Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia
title_fullStr	Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia
title_full_unstemmed	Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia
title_sort	adhesion molecules involved in stem cell niche retention during normal haematopoiesis and in acute myeloid leukaemia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/71651b1cfd9d47078cabce2a3a0be5cf
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Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid Leukaemia

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