PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.

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Autores principales:	Jinxue He, Zhong Zhang, Meng Ouyang, Fan Yang, Hongbo Hao, Kristy L. Lamb, Jingyi Yang, Yuxin Yin, Wen H. Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/716f9f6bf99143419ad37665f32dfb7a
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spelling	oai:doaj.org-article:716f9f6bf99143419ad37665f32dfb7a2021-12-02T17:32:22ZPTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis10.1038/ncomms123552041-1723https://doaj.org/article/716f9f6bf99143419ad37665f32dfb7a2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12355https://doaj.org/toc/2041-1723One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.Jinxue HeZhong ZhangMeng OuyangFan YangHongbo HaoKristy L. LambJingyi YangYuxin YinWen H. ShenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinxue He Zhong Zhang Meng Ouyang Fan Yang Hongbo Hao Kristy L. Lamb Jingyi Yang Yuxin Yin Wen H. Shen PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
description	One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.
format	article
author	Jinxue He Zhong Zhang Meng Ouyang Fan Yang Hongbo Hao Kristy L. Lamb Jingyi Yang Yuxin Yin Wen H. Shen
author_facet	Jinxue He Zhong Zhang Meng Ouyang Fan Yang Hongbo Hao Kristy L. Lamb Jingyi Yang Yuxin Yin Wen H. Shen
author_sort	Jinxue He
title	PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
title_short	PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
title_full	PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
title_fullStr	PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
title_full_unstemmed	PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis
title_sort	pten regulates eg5 to control spindle architecture and chromosome congression during mitosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/716f9f6bf99143419ad37665f32dfb7a
work_keys_str_mv	AT jinxuehe ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis AT zhongzhang ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis AT mengouyang ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis AT fanyang ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis AT hongbohao ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis AT kristyllamb ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis AT jingyiyang ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis AT yuxinyin ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis AT wenhshen ptenregulateseg5tocontrolspindlearchitectureandchromosomecongressionduringmitosis
_version_	1718380314120683520

PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

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