PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis

One of the cellular functions of the tumour suppressor PTEN is to maintain genome stability. Here, the authors show that PTEN depletion leads to mitotic spindle shortening and chromosome misalignment due to aberrant EG5 activation.

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Autores principales: Jinxue He, Zhong Zhang, Meng Ouyang, Fan Yang, Hongbo Hao, Kristy L. Lamb, Jingyi Yang, Yuxin Yin, Wen H. Shen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/716f9f6bf99143419ad37665f32dfb7a
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