Nav channel binder containing a specific conjugation-site based on a low toxicity β-scorpion toxin

Abstract Voltage-gated sodium (Nav) channels play a key role in generating action potentials which leads to physiological signaling in excitable cells. The availability of probes for functional studies of mammalian Nav is limited. Here, by introducing two amino acid substitutions into the beta scorp...

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Autores principales: Tomoya Kubota, Bobo Dang, Joao L. Carvalho-de-Souza, Ana M. Correa, Francisco Bezanilla
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/7170acf415be445fb7788f6811099f0f
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