Nav channel binder containing a specific conjugation-site based on a low toxicity β-scorpion toxin
Abstract Voltage-gated sodium (Nav) channels play a key role in generating action potentials which leads to physiological signaling in excitable cells. The availability of probes for functional studies of mammalian Nav is limited. Here, by introducing two amino acid substitutions into the beta scorp...
Guardado en:
Autores principales: | Tomoya Kubota, Bobo Dang, Joao L. Carvalho-de-Souza, Ana M. Correa, Francisco Bezanilla |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/7170acf415be445fb7788f6811099f0f |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Direct evidence that scorpion α-toxins (site-3) modulate sodium channel inactivation by hindrance of voltage-sensor movements.
por: Zhongming Ma, et al.
Publicado: (2013) -
Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
por: Daohua Jiang, et al.
Publicado: (2021) -
Identification of Navβ1 residues involved in the modulation of the sodium channel Nav1.4.
por: Angel A Islas, et al.
Publicado: (2013) -
Global transcriptome analysis of the scorpion Centruroides noxius: new toxin families and evolutionary insights from an ancestral scorpion species.
por: Martha Rendón-Anaya, et al.
Publicado: (2012) -
Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels
por: Xi Zhou, et al.
Publicado: (2020)