Twelve-Month Outcomes of Stand-Alone Excisional Goniotomy in Mild to Severe Glaucoma
Mohammed K ElMallah,1 John P Berdahl,2 Blake K Williamson,3 Syril K Dorairaj,4 Malik Y Kahook,5 Mark J Gallardo,6 Ahad Mahootchi,7 Sanjay N Smith,8 Leonard A Rappaport,9 Daniela Diaz-Robles,10 Gabriel S Lazcano-Gomez11 1Ocala Eye, Ocala, FL, USA; 2Vance Thompson Vision, Sioux Falls, SD, USA; 3Willia...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2020
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| Acceso en línea: | https://doaj.org/article/7170eb927cff461b9640f1f6a81fc286 |
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| Sumario: | Mohammed K ElMallah,1 John P Berdahl,2 Blake K Williamson,3 Syril K Dorairaj,4 Malik Y Kahook,5 Mark J Gallardo,6 Ahad Mahootchi,7 Sanjay N Smith,8 Leonard A Rappaport,9 Daniela Diaz-Robles,10 Gabriel S Lazcano-Gomez11 1Ocala Eye, Ocala, FL, USA; 2Vance Thompson Vision, Sioux Falls, SD, USA; 3Williamson Eye Center, Baton Rouge, LA, USA; 4Mayo Clinic, Jacksonville, FL, USA; 5University of Colorado, Aurora, CO, USA; 6El Paso Eye Surgeons, El Paso, TX, USA; 7The Eye Clinic of Florida, Zephyrhills, FL, USA; 8Medical Eye Associates, South Miami, FL, USA; 9Tidewater Eye Centers, Portsmouth, VA, USA; 10Clinica Santa Lucia, Guadalajara, Mexico; 11Asociacion Para Evitar Le Ceguera (APEC), Mexico City, MexicoCorrespondence: Mohammed K ElMallah Email elmallah@ocalaeye.comPurpose: To describe 12-month intraocular pressure (IOP) and medication use outcomes following excisional goniotomy (EG) as a stand-alone procedure in eyes with medically uncontrolled glaucoma.Methods: This was a retrospective analysis of data from surgeons at 8 centers (6 US, 2 Mexico). Eyes with glaucoma undergoing standalone EG with a specialized instrument (Kahook Dual Blade, New World Medical, Rancho Cucamonga, CA) for IOP reduction and followed for 12 months postoperatively were included. Data were collected preoperatively, intraoperatively, and 1 day, 1 week, and 1, 3, 6, and 12 months postoperatively. The primary outcome was reduction from baseline in IOP, and key secondary outcomes included IOP-lowering medication reduction as well as adverse events.Results: A total of 42 eyes were analyzed, of which 36 (85.7%) had mild to severe primary open-angle glaucoma (POAG). Mean (standard error) IOP at baseline was 21.6 (0.8) mmHg, and mean number of medications used at baseline was 2.6 (0.2). At 3, 6, and 12 months postoperatively, mean IOP reductions from baseline were 4.6 mmHg (22.3%), 5.6 mmHg (27.7%), and 3.9 mmHg (19.3%) (p≤ 0.001 at each time point). At the same time points, mean medications reductions of 0.7 (25.8%), 0.9 (32.6%), and 0.3 (12.5%) medications were seen (p< 0.05 at months 3 and 6, not significant at month 12). Six eyes (14.3%) underwent additional glaucoma surgery during the 12-month follow-up period.Discussion: Standalone EG with KDB can reduce IOP, and in many cases reduce medication use, through up to 12 months in eyes with mild to severe glaucoma. Statistically significant and clinically relevant reductions in IOP were seen at every time point. While the goal of surgery was not to reduce medication burden, mean medication use was significantly reduced at all but the last time point. In the majority of eyes, the need for a bleb-based glaucoma procedure was delayed or prevented for at least 12 months.Keywords: glaucoma, standalone, Kahook dual blade, goniotomy |
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