Increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia

Koichi Nisijima Department of Psychiatry, Jichi Medical University, Tochigi, Japan Abstract: The pathophysiology of malignant catatonia, a rare life-threatening psychiatric syndrome, has not yet been elucidated. This paper reports on two patients with malignant catatonia who showed elevated urinary...

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Autor principal:	Nisijima K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/71725685f61f4fa38b9f6acb6b9880d9
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spelling	oai:doaj.org-article:71725685f61f4fa38b9f6acb6b9880d92021-12-02T00:06:32ZIncreased biogenic catecholamine and metabolite levels in two patients with malignant catatonia1176-63281178-2021https://doaj.org/article/71725685f61f4fa38b9f6acb6b9880d92013-08-01T00:00:00Zhttp://www.dovepress.com/increased-biogenic-catecholamine-and-metabolite-levels-in-two-patients-a14001https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Koichi Nisijima Department of Psychiatry, Jichi Medical University, Tochigi, Japan Abstract: The pathophysiology of malignant catatonia, a rare life-threatening psychiatric syndrome, has not yet been elucidated. This paper reports on two patients with malignant catatonia who showed elevated urinary or plasma catecholamine levels. Patient 1 had high catecholamine and metabolite levels in a 24-hour urine sample, and patient 2 had elevated plasma catecholamine levels. These findings indicate the presence of peripheral sympathetic nervous system hyperactivity in malignant catatonia. Symptoms of autonomic dysfunction, including tachycardia, labile blood pressure, and diaphoresis, are typical features of malignant catatonia and may be related to the increased levels of biogenic amines in these cases. Although the findings in the present study cannot entirely explain the pathophysiology of malignant catatonia, they do indicate that hyperactivity of the sympathetic nervous system may be involved in the pathology of this condition. Keywords: malignant catatonia, catecholamine levels, neuroleptic malignant syndromeNisijima KDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1171-1174 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Nisijima K Increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia
description	Koichi Nisijima Department of Psychiatry, Jichi Medical University, Tochigi, Japan Abstract: The pathophysiology of malignant catatonia, a rare life-threatening psychiatric syndrome, has not yet been elucidated. This paper reports on two patients with malignant catatonia who showed elevated urinary or plasma catecholamine levels. Patient 1 had high catecholamine and metabolite levels in a 24-hour urine sample, and patient 2 had elevated plasma catecholamine levels. These findings indicate the presence of peripheral sympathetic nervous system hyperactivity in malignant catatonia. Symptoms of autonomic dysfunction, including tachycardia, labile blood pressure, and diaphoresis, are typical features of malignant catatonia and may be related to the increased levels of biogenic amines in these cases. Although the findings in the present study cannot entirely explain the pathophysiology of malignant catatonia, they do indicate that hyperactivity of the sympathetic nervous system may be involved in the pathology of this condition. Keywords: malignant catatonia, catecholamine levels, neuroleptic malignant syndrome
format	article
author	Nisijima K
author_facet	Nisijima K
author_sort	Nisijima K
title	Increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia
title_short	Increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia
title_full	Increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia
title_fullStr	Increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia
title_full_unstemmed	Increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia
title_sort	increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/71725685f61f4fa38b9f6acb6b9880d9
work_keys_str_mv	AT nisijimak increasedbiogeniccatecholamineandmetabolitelevelsintwopatientswithmalignantcatatonia
_version_	1718403934942396416

Increased biogenic catecholamine and metabolite levels in two patients with malignant catatonia

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