Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. Currently, treatments available for advanced HCC provide dismal chances of survival, thus there is an urgent need to develop more effective therapeutic strategies. While much of the focus of recent decades has bee...

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Autores principales:	Tamás Sükei, Elena Palma, Luca Urbani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	extracellular matrix liver cancer tumour microenvironment bioengineering 3D models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/71731201c0684fb083bc8b2c64feae90
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spelling	oai:doaj.org-article:71731201c0684fb083bc8b2c64feae902021-11-11T15:36:07ZInterplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma10.3390/cancers132155862072-6694https://doaj.org/article/71731201c0684fb083bc8b2c64feae902021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5586https://doaj.org/toc/2072-6694Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. Currently, treatments available for advanced HCC provide dismal chances of survival, thus there is an urgent need to develop more effective therapeutic strategies. While much of the focus of recent decades has been on targeting malignant cells, promising results have emerged from targeting the tumour microenvironment (TME). The extracellular matrix (ECM) is the main non-cellular component of the TME and it profoundly changes during tumorigenesis to promote the growth and survival of malignant cells. Despite this, many in vitro models for drug testing fail to consider the TME leading to a high failure rate in clinical trials. Here, we present an overview of the function and properties of the ECM in the liver and how these change during malignant transformation. We also discuss the relationship between immune cells and ECM in the TME in HCC. Lastly, we present advanced, 3D culture techniques of cancer modelling and argue that the incorporation of TME components into these is essential to better recapitulate the complex interactions within the TME.Tamás SükeiElena PalmaLuca UrbaniMDPI AGarticleextracellular matrixliver cancertumour microenvironmentbioengineering3D modelsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5586, p 5586 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular matrix liver cancer tumour microenvironment bioengineering 3D models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	extracellular matrix liver cancer tumour microenvironment bioengineering 3D models Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Tamás Sükei Elena Palma Luca Urbani Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma
description	Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. Currently, treatments available for advanced HCC provide dismal chances of survival, thus there is an urgent need to develop more effective therapeutic strategies. While much of the focus of recent decades has been on targeting malignant cells, promising results have emerged from targeting the tumour microenvironment (TME). The extracellular matrix (ECM) is the main non-cellular component of the TME and it profoundly changes during tumorigenesis to promote the growth and survival of malignant cells. Despite this, many in vitro models for drug testing fail to consider the TME leading to a high failure rate in clinical trials. Here, we present an overview of the function and properties of the ECM in the liver and how these change during malignant transformation. We also discuss the relationship between immune cells and ECM in the TME in HCC. Lastly, we present advanced, 3D culture techniques of cancer modelling and argue that the incorporation of TME components into these is essential to better recapitulate the complex interactions within the TME.
format	article
author	Tamás Sükei Elena Palma Luca Urbani
author_facet	Tamás Sükei Elena Palma Luca Urbani
author_sort	Tamás Sükei
title	Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma
title_short	Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma
title_full	Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma
title_fullStr	Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma
title_full_unstemmed	Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma
title_sort	interplay between cellular and non-cellular components of the tumour microenvironment in hepatocellular carcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/71731201c0684fb083bc8b2c64feae90
work_keys_str_mv	AT tamassukei interplaybetweencellularandnoncellularcomponentsofthetumourmicroenvironmentinhepatocellularcarcinoma AT elenapalma interplaybetweencellularandnoncellularcomponentsofthetumourmicroenvironmentinhepatocellularcarcinoma AT lucaurbani interplaybetweencellularandnoncellularcomponentsofthetumourmicroenvironmentinhepatocellularcarcinoma
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Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma

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