Hypofractionated whole breast radiotherapy: current perspectives

Hypofractionated whole breast radiotherapy: current perspectives

Theodora A Koulis, Tien Phan, Ivo A Olivotto Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, AB, Canada Abstract: Adjuvant radiotherapy (RT) is an important part of breast cancer management but the dose and fractionation schedules used are variable. A total of 50 Gy...

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Autores principales: Koulis TA, Phan T, Olivotto IA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/71752a5c1f8f4175b09e57ed0052c00f
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spelling oai:doaj.org-article:71752a5c1f8f4175b09e57ed0052c00f2021-12-02T06:49:40ZHypofractionated whole breast radiotherapy: current perspectives1179-1314https://doaj.org/article/71752a5c1f8f4175b09e57ed0052c00f2015-10-01T00:00:00Zhttps://www.dovepress.com/hypofractionated-whole-breast-radiotherapy-current-perspectives-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Theodora A Koulis, Tien Phan, Ivo A Olivotto Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, AB, Canada Abstract: Adjuvant radiotherapy (RT) is an important part of breast cancer management but the dose and fractionation schedules used are variable. A total of 50 Gy in 25 daily fractions delivered over 5 weeks is often considered the "standard" adjuvant RT prescription. Hypofractionated regimes such as 42.5 Gy in 16 daily fractions or 40 Gy in 15 daily fractions following breast-conserving surgery have proven to be equally effective and achieve similar or better cosmetic and normal tissue outcomes for both invasive and in situ diseases and when treating the regional nodes. Hypofractionation is more convenient for patients and less costly. However, certain patients at higher risk of RT late effects may benefit from a less intense, even more extended fractionation schedule. This review describes the indications for whole breast hypofractionated adjuvant RT for patients with breast cancer following breast-conserving surgery and proposes that hypofractionation should be the new "standard" for adjuvant breast cancer RT. Keywords: fractionation, breast cancer, cosmesis, radiotherapyKoulis TAPhan TOlivotto IADove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2015, Iss default, Pp 363-370 (2015)
institution DOAJ
collection DOAJ
language EN
topic Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Koulis TA
Phan T
Olivotto IA
Hypofractionated whole breast radiotherapy: current perspectives
description Theodora A Koulis, Tien Phan, Ivo A Olivotto Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, AB, Canada Abstract: Adjuvant radiotherapy (RT) is an important part of breast cancer management but the dose and fractionation schedules used are variable. A total of 50 Gy in 25 daily fractions delivered over 5 weeks is often considered the "standard" adjuvant RT prescription. Hypofractionated regimes such as 42.5 Gy in 16 daily fractions or 40 Gy in 15 daily fractions following breast-conserving surgery have proven to be equally effective and achieve similar or better cosmetic and normal tissue outcomes for both invasive and in situ diseases and when treating the regional nodes. Hypofractionation is more convenient for patients and less costly. However, certain patients at higher risk of RT late effects may benefit from a less intense, even more extended fractionation schedule. This review describes the indications for whole breast hypofractionated adjuvant RT for patients with breast cancer following breast-conserving surgery and proposes that hypofractionation should be the new "standard" for adjuvant breast cancer RT. Keywords: fractionation, breast cancer, cosmesis, radiotherapy
format article
author Koulis TA
Phan T
Olivotto IA
author_facet Koulis TA
Phan T
Olivotto IA
author_sort Koulis TA
title Hypofractionated whole breast radiotherapy: current perspectives
title_short Hypofractionated whole breast radiotherapy: current perspectives
title_full Hypofractionated whole breast radiotherapy: current perspectives
title_fullStr Hypofractionated whole breast radiotherapy: current perspectives
title_full_unstemmed Hypofractionated whole breast radiotherapy: current perspectives
title_sort hypofractionated whole breast radiotherapy: current perspectives
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/71752a5c1f8f4175b09e57ed0052c00f
work_keys_str_mv AT koulista hypofractionatedwholebreastradiotherapycurrentperspectives
AT phant hypofractionatedwholebreastradiotherapycurrentperspectives
AT olivottoia hypofractionatedwholebreastradiotherapycurrentperspectives
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