Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators
Abstract Clinical studies with modulators of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein have demonstrated that functional restoration of the mutated CFTR can lead to substantial clinical benefit. However, studies have shown highly variable patient responses. The objective...
Guardado en:
Autores principales: | Iwona M. Pranke, Aurélie Hatton, Juliette Simonin, Jean Philippe Jais, Françoise Le Pimpec-Barthes, Ania Carsin, Pierre Bonnette, Michael Fayon, Nathalie Stremler-Le Bel, Dominique Grenet, Matthieu Thumerel, Julie Mazenq, Valerie Urbach, Myriam Mesbahi, Emanuelle Girodon-Boulandet, Alexandre Hinzpeter, Aleksander Edelman, Isabelle Sermet-Gaudelus |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/71753db8957441c5881e8e0b86b29dbf |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation
por: Sara Bitam, et al.
Publicado: (2021) -
Author Correction: New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation
por: Sara Bitam, et al.
Publicado: (2021) -
CFTR Protein: Not Just a Chloride Channel?
por: Laurence S. Hanssens, et al.
Publicado: (2021) -
Impact of Airway Inflammation on the Efficacy of CFTR Modulators
por: Carla M. P. Ribeiro, et al.
Publicado: (2021) -
The Distribution and Role of the CFTR Protein in the Intracellular Compartments
por: Agnieszka Lukasiak, et al.
Publicado: (2021)