The Roles of Serotonin in Decision-making under Social Group Conditions

Abstract People in a social group often have to make decisions under conflict, for instance, to conform to the group or obey authority (subjects at higher social rank in the group). The neural mechanisms underlying how social group setting affects decision-making have largely remained unclear. In th...

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Autores principales:	Young-A Lee, Yukiori Goto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/717594bf8da6418284e698a18f3374d7
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spelling	oai:doaj.org-article:717594bf8da6418284e698a18f3374d72021-12-02T15:08:51ZThe Roles of Serotonin in Decision-making under Social Group Conditions10.1038/s41598-018-29055-92045-2322https://doaj.org/article/717594bf8da6418284e698a18f3374d72018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29055-9https://doaj.org/toc/2045-2322Abstract People in a social group often have to make decisions under conflict, for instance, to conform to the group or obey authority (subjects at higher social rank in the group). The neural mechanisms underlying how social group setting affects decision-making have largely remained unclear. In this study, we designed novel behavioral tests using food access priority and fear conditioning paradigms that captured decision-making under conflict associated with social group environments in mice and examined the roles of serotonin (5-HT) on these processes. Using these behavioral tests, administration of the selective 5-HT reuptake inhibitor, which increased 5-HT transmission, was found to attenuate conflicts in decision-making that may be associated with human cases of social obedience and conformity in mice under group housing. The results suggest that 5-HT plays important roles in the regulation of individual behaviors that organize social group dynamics.Young-A LeeYukiori GotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Young-A Lee Yukiori Goto The Roles of Serotonin in Decision-making under Social Group Conditions
description	Abstract People in a social group often have to make decisions under conflict, for instance, to conform to the group or obey authority (subjects at higher social rank in the group). The neural mechanisms underlying how social group setting affects decision-making have largely remained unclear. In this study, we designed novel behavioral tests using food access priority and fear conditioning paradigms that captured decision-making under conflict associated with social group environments in mice and examined the roles of serotonin (5-HT) on these processes. Using these behavioral tests, administration of the selective 5-HT reuptake inhibitor, which increased 5-HT transmission, was found to attenuate conflicts in decision-making that may be associated with human cases of social obedience and conformity in mice under group housing. The results suggest that 5-HT plays important roles in the regulation of individual behaviors that organize social group dynamics.
format	article
author	Young-A Lee Yukiori Goto
author_facet	Young-A Lee Yukiori Goto
author_sort	Young-A Lee
title	The Roles of Serotonin in Decision-making under Social Group Conditions
title_short	The Roles of Serotonin in Decision-making under Social Group Conditions
title_full	The Roles of Serotonin in Decision-making under Social Group Conditions
title_fullStr	The Roles of Serotonin in Decision-making under Social Group Conditions
title_full_unstemmed	The Roles of Serotonin in Decision-making under Social Group Conditions
title_sort	roles of serotonin in decision-making under social group conditions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/717594bf8da6418284e698a18f3374d7
work_keys_str_mv	AT youngalee therolesofserotoninindecisionmakingundersocialgroupconditions AT yukiorigoto therolesofserotoninindecisionmakingundersocialgroupconditions AT youngalee rolesofserotoninindecisionmakingundersocialgroupconditions AT yukiorigoto rolesofserotoninindecisionmakingundersocialgroupconditions
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The Roles of Serotonin in Decision-making under Social Group Conditions

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