Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture

Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture

Enhancer RNAs are transcribed bidirectionally from core transcription initiation regions. Here, by employing nascent RNA sequencing, the authors identify quantitative trait loci (QTLs) associated with enhancer RNA level and directionality, revealing the bipartite architecture of enhancers.

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Autores principales: Katla Kristjánsdóttir, Alexis Dziubek, Hyun Min Kang, Hojoong Kwak
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/717671be17124b458fe0fc9bad99be2f
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spelling oai:doaj.org-article:717671be17124b458fe0fc9bad99be2f2021-12-02T14:16:56ZPopulation-scale study of eRNA transcription reveals bipartite functional enhancer architecture10.1038/s41467-020-19829-z2041-1723https://doaj.org/article/717671be17124b458fe0fc9bad99be2f2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19829-zhttps://doaj.org/toc/2041-1723Enhancer RNAs are transcribed bidirectionally from core transcription initiation regions. Here, by employing nascent RNA sequencing, the authors identify quantitative trait loci (QTLs) associated with enhancer RNA level and directionality, revealing the bipartite architecture of enhancers.Katla KristjánsdóttirAlexis DziubekHyun Min KangHojoong KwakNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Katla Kristjánsdóttir
Alexis Dziubek
Hyun Min Kang
Hojoong Kwak
Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
description Enhancer RNAs are transcribed bidirectionally from core transcription initiation regions. Here, by employing nascent RNA sequencing, the authors identify quantitative trait loci (QTLs) associated with enhancer RNA level and directionality, revealing the bipartite architecture of enhancers.
format article
author Katla Kristjánsdóttir
Alexis Dziubek
Hyun Min Kang
Hojoong Kwak
author_facet Katla Kristjánsdóttir
Alexis Dziubek
Hyun Min Kang
Hojoong Kwak
author_sort Katla Kristjánsdóttir
title Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
title_short Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
title_full Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
title_fullStr Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
title_full_unstemmed Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
title_sort population-scale study of erna transcription reveals bipartite functional enhancer architecture
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/717671be17124b458fe0fc9bad99be2f
work_keys_str_mv AT katlakristjansdottir populationscalestudyofernatranscriptionrevealsbipartitefunctionalenhancerarchitecture
AT alexisdziubek populationscalestudyofernatranscriptionrevealsbipartitefunctionalenhancerarchitecture
AT hyunminkang populationscalestudyofernatranscriptionrevealsbipartitefunctionalenhancerarchitecture
AT hojoongkwak populationscalestudyofernatranscriptionrevealsbipartitefunctionalenhancerarchitecture
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