Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein

Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein

The tumor suppressor gene DLC1 can be downregulated in cancers through genetic and non-genetic mechanisms. Here, the authors show cytoplasmic EZH2 can directly methylate and destabilize the DLC1 protein, and EZH2 inhibition can increase the DLC1 protein half-life at least 20-fold.

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Detalles Bibliográficos
Autores principales: Brajendra K. Tripathi, Meghan F. Anderman, Disha Bhargava, Luciarita Boccuzzi, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Alex G. Papageorge, Fernando J. de Miguel, Katerina Politi, Kylie J. Walters, James H. Doroshow, Douglas R. Lowy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/7176f11d2bb2458e8f04d65843a147be
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Sumario:The tumor suppressor gene DLC1 can be downregulated in cancers through genetic and non-genetic mechanisms. Here, the authors show cytoplasmic EZH2 can directly methylate and destabilize the DLC1 protein, and EZH2 inhibition can increase the DLC1 protein half-life at least 20-fold.

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