Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein

The tumor suppressor gene DLC1 can be downregulated in cancers through genetic and non-genetic mechanisms. Here, the authors show cytoplasmic EZH2 can directly methylate and destabilize the DLC1 protein, and EZH2 inhibition can increase the DLC1 protein half-life at least 20-fold.

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Autores principales:	Brajendra K. Tripathi, Meghan F. Anderman, Disha Bhargava, Luciarita Boccuzzi, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Alex G. Papageorge, Fernando J. de Miguel, Katerina Politi, Kylie J. Walters, James H. Doroshow, Douglas R. Lowy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7176f11d2bb2458e8f04d65843a147be
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spelling	oai:doaj.org-article:7176f11d2bb2458e8f04d65843a147be2021-12-05T12:22:07ZInhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein10.1038/s41467-021-26993-32041-1723https://doaj.org/article/7176f11d2bb2458e8f04d65843a147be2021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26993-3https://doaj.org/toc/2041-1723The tumor suppressor gene DLC1 can be downregulated in cancers through genetic and non-genetic mechanisms. Here, the authors show cytoplasmic EZH2 can directly methylate and destabilize the DLC1 protein, and EZH2 inhibition can increase the DLC1 protein half-life at least 20-fold.Brajendra K. TripathiMeghan F. AndermanDisha BhargavaLuciarita BoccuzziXiaolan QianDunrui WangMarian E. DurkinAlex G. PapageorgeFernando J. de MiguelKaterina PolitiKylie J. WaltersJames H. DoroshowDouglas R. LowyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brajendra K. Tripathi Meghan F. Anderman Disha Bhargava Luciarita Boccuzzi Xiaolan Qian Dunrui Wang Marian E. Durkin Alex G. Papageorge Fernando J. de Miguel Katerina Politi Kylie J. Walters James H. Doroshow Douglas R. Lowy Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein
description	The tumor suppressor gene DLC1 can be downregulated in cancers through genetic and non-genetic mechanisms. Here, the authors show cytoplasmic EZH2 can directly methylate and destabilize the DLC1 protein, and EZH2 inhibition can increase the DLC1 protein half-life at least 20-fold.
format	article
author	Brajendra K. Tripathi Meghan F. Anderman Disha Bhargava Luciarita Boccuzzi Xiaolan Qian Dunrui Wang Marian E. Durkin Alex G. Papageorge Fernando J. de Miguel Katerina Politi Kylie J. Walters James H. Doroshow Douglas R. Lowy
author_facet	Brajendra K. Tripathi Meghan F. Anderman Disha Bhargava Luciarita Boccuzzi Xiaolan Qian Dunrui Wang Marian E. Durkin Alex G. Papageorge Fernando J. de Miguel Katerina Politi Kylie J. Walters James H. Doroshow Douglas R. Lowy
author_sort	Brajendra K. Tripathi
title	Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein
title_short	Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein
title_full	Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein
title_fullStr	Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein
title_full_unstemmed	Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein
title_sort	inhibition of cytoplasmic ezh2 induces antitumor activity through stabilization of the dlc1 tumor suppressor protein
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7176f11d2bb2458e8f04d65843a147be
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Inhibition of cytoplasmic EZH2 induces antitumor activity through stabilization of the DLC1 tumor suppressor protein

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