Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance

How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Haohao Huang, Songyang Zhang, Yuanyuan Li, Zhaodan Liu, Lanjuan Mi, Yan Cai, Xinzheng Wang, Lishu Chen, Haowen Ran, Dake Xiao, Fangye Li, Jiaqi Wu, Tingting Li, Qiuying Han, Liang Chen, Xin Pan, Huiyan Li, Tao Li, Kun He, Ailing Li, Xuemin Zhang, Tao Zhou, Qing Xia, Jianghong Man
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/717939013c2d493084da56349c8594b5
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:717939013c2d493084da56349c8594b5
record_format dspace
spelling oai:doaj.org-article:717939013c2d493084da56349c8594b52021-12-02T17:40:00ZSuppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance10.1038/s41467-021-24108-62041-1723https://doaj.org/article/717939013c2d493084da56349c8594b52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24108-6https://doaj.org/toc/2041-1723How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells.Haohao HuangSongyang ZhangYuanyuan LiZhaodan LiuLanjuan MiYan CaiXinzheng WangLishu ChenHaowen RanDake XiaoFangye LiJiaqi WuTingting LiQiuying HanLiang ChenXin PanHuiyan LiTao LiKun HeAiling LiXuemin ZhangTao ZhouQing XiaJianghong ManNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Haohao Huang
Songyang Zhang
Yuanyuan Li
Zhaodan Liu
Lanjuan Mi
Yan Cai
Xinzheng Wang
Lishu Chen
Haowen Ran
Dake Xiao
Fangye Li
Jiaqi Wu
Tingting Li
Qiuying Han
Liang Chen
Xin Pan
Huiyan Li
Tao Li
Kun He
Ailing Li
Xuemin Zhang
Tao Zhou
Qing Xia
Jianghong Man
Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
description How ROS levels are regulated in cancer stem cells and their contribution to cancer resistance is currently not clear. Here, the authors show that prohibitin regulates mitochondrial ROS production stabilizing the peroxidase PRDX3 and this accounts for radiotherapy resistance in glioma stem-like cells.
format article
author Haohao Huang
Songyang Zhang
Yuanyuan Li
Zhaodan Liu
Lanjuan Mi
Yan Cai
Xinzheng Wang
Lishu Chen
Haowen Ran
Dake Xiao
Fangye Li
Jiaqi Wu
Tingting Li
Qiuying Han
Liang Chen
Xin Pan
Huiyan Li
Tao Li
Kun He
Ailing Li
Xuemin Zhang
Tao Zhou
Qing Xia
Jianghong Man
author_facet Haohao Huang
Songyang Zhang
Yuanyuan Li
Zhaodan Liu
Lanjuan Mi
Yan Cai
Xinzheng Wang
Lishu Chen
Haowen Ran
Dake Xiao
Fangye Li
Jiaqi Wu
Tingting Li
Qiuying Han
Liang Chen
Xin Pan
Huiyan Li
Tao Li
Kun He
Ailing Li
Xuemin Zhang
Tao Zhou
Qing Xia
Jianghong Man
author_sort Haohao Huang
title Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
title_short Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
title_full Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
title_fullStr Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
title_full_unstemmed Suppression of mitochondrial ROS by prohibitin drives glioblastoma progression and therapeutic resistance
title_sort suppression of mitochondrial ros by prohibitin drives glioblastoma progression and therapeutic resistance
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/717939013c2d493084da56349c8594b5
work_keys_str_mv AT haohaohuang suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT songyangzhang suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT yuanyuanli suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT zhaodanliu suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT lanjuanmi suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT yancai suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT xinzhengwang suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT lishuchen suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT haowenran suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT dakexiao suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT fangyeli suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT jiaqiwu suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT tingtingli suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT qiuyinghan suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT liangchen suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT xinpan suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT huiyanli suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT taoli suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT kunhe suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT ailingli suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT xueminzhang suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT taozhou suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT qingxia suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
AT jianghongman suppressionofmitochondrialrosbyprohibitindrivesglioblastomaprogressionandtherapeuticresistance
_version_ 1718379769571049472

Ejemplares similares