Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.

<h4>Background</h4>We assessed the severity of the 2009 influenza pandemic by comparing pandemic mortality to seasonal influenza mortality. However, reported pandemic deaths were laboratory-confirmed - and thus an underestimation - whereas seasonal influenza mortality is often more inclu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cees C van den Wijngaard, Liselotte van Asten, Marion P G Koopmans, Wilfrid van Pelt, Nico J D Nagelkerke, Cornelia C H Wielders, Alies van Lier, Wim van der Hoek, Adam Meijer, Gé A Donker, Frederika Dijkstra, Carel Harmsen, Marianne A B van der Sande, Mirjam Kretzschmar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/717a8511a7ac4fb6a4c28a46a87396ea
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:717a8511a7ac4fb6a4c28a46a87396ea
record_format	dspace
spelling	oai:doaj.org-article:717a8511a7ac4fb6a4c28a46a87396ea2021-11-18T07:28:52ZComparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.1932-620310.1371/journal.pone.0031197https://doaj.org/article/717a8511a7ac4fb6a4c28a46a87396ea2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22319616/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>We assessed the severity of the 2009 influenza pandemic by comparing pandemic mortality to seasonal influenza mortality. However, reported pandemic deaths were laboratory-confirmed - and thus an underestimation - whereas seasonal influenza mortality is often more inclusively estimated. For a valid comparison, our study used the same statistical methodology and data types to estimate pandemic and seasonal influenza mortality.<h4>Methods and findings</h4>We used data on all-cause mortality (1999-2010, 100% coverage, 16.5 million Dutch population) and influenza-like-illness (ILI) incidence (0.8% coverage). Data was aggregated by week and age category. Using generalized estimating equation regression models, we attributed mortality to influenza by associating mortality with ILI-incidence, while adjusting for annual shifts in association. We also adjusted for respiratory syncytial virus, hot/cold weather, other seasonal factors and autocorrelation. For the 2009 pandemic season, we estimated 612 (range 266-958) influenza-attributed deaths; for seasonal influenza 1,956 (range 0-3,990). 15,845 years-of-life-lost were estimated for the pandemic; for an average seasonal epidemic 17,908. For 0-4 yrs of age the number of influenza-attributed deaths during the pandemic were higher than in any seasonal epidemic; 77 deaths (range 61-93) compared to 16 deaths (range 0-45). The ≥75 yrs of age showed a far below average number of deaths. Using pneumonia/influenza and respiratory/cardiovascular instead of all-cause deaths consistently resulted in relatively low total pandemic mortality, combined with high impact in the youngest age category.<h4>Conclusion</h4>The pandemic had an overall moderate impact on mortality compared to 10 preceding seasonal epidemics, with higher mortality in young children and low mortality in the elderly. This resulted in a total number of pandemic deaths far below the average for seasonal influenza, and a total number of years-of-life-lost somewhat below average. Comparing pandemic and seasonal influenza mortality as in our study will help assessing the worldwide impact of the 2009 pandemic.Cees C van den WijngaardLiselotte van AstenMarion P G KoopmansWilfrid van PeltNico J D NagelkerkeCornelia C H WieldersAlies van LierWim van der HoekAdam MeijerGé A DonkerFrederika DijkstraCarel HarmsenMarianne A B van der SandeMirjam KretzschmarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31197 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cees C van den Wijngaard Liselotte van Asten Marion P G Koopmans Wilfrid van Pelt Nico J D Nagelkerke Cornelia C H Wielders Alies van Lier Wim van der Hoek Adam Meijer Gé A Donker Frederika Dijkstra Carel Harmsen Marianne A B van der Sande Mirjam Kretzschmar Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.
description	<h4>Background</h4>We assessed the severity of the 2009 influenza pandemic by comparing pandemic mortality to seasonal influenza mortality. However, reported pandemic deaths were laboratory-confirmed - and thus an underestimation - whereas seasonal influenza mortality is often more inclusively estimated. For a valid comparison, our study used the same statistical methodology and data types to estimate pandemic and seasonal influenza mortality.<h4>Methods and findings</h4>We used data on all-cause mortality (1999-2010, 100% coverage, 16.5 million Dutch population) and influenza-like-illness (ILI) incidence (0.8% coverage). Data was aggregated by week and age category. Using generalized estimating equation regression models, we attributed mortality to influenza by associating mortality with ILI-incidence, while adjusting for annual shifts in association. We also adjusted for respiratory syncytial virus, hot/cold weather, other seasonal factors and autocorrelation. For the 2009 pandemic season, we estimated 612 (range 266-958) influenza-attributed deaths; for seasonal influenza 1,956 (range 0-3,990). 15,845 years-of-life-lost were estimated for the pandemic; for an average seasonal epidemic 17,908. For 0-4 yrs of age the number of influenza-attributed deaths during the pandemic were higher than in any seasonal epidemic; 77 deaths (range 61-93) compared to 16 deaths (range 0-45). The ≥75 yrs of age showed a far below average number of deaths. Using pneumonia/influenza and respiratory/cardiovascular instead of all-cause deaths consistently resulted in relatively low total pandemic mortality, combined with high impact in the youngest age category.<h4>Conclusion</h4>The pandemic had an overall moderate impact on mortality compared to 10 preceding seasonal epidemics, with higher mortality in young children and low mortality in the elderly. This resulted in a total number of pandemic deaths far below the average for seasonal influenza, and a total number of years-of-life-lost somewhat below average. Comparing pandemic and seasonal influenza mortality as in our study will help assessing the worldwide impact of the 2009 pandemic.
format	article
author	Cees C van den Wijngaard Liselotte van Asten Marion P G Koopmans Wilfrid van Pelt Nico J D Nagelkerke Cornelia C H Wielders Alies van Lier Wim van der Hoek Adam Meijer Gé A Donker Frederika Dijkstra Carel Harmsen Marianne A B van der Sande Mirjam Kretzschmar
author_facet	Cees C van den Wijngaard Liselotte van Asten Marion P G Koopmans Wilfrid van Pelt Nico J D Nagelkerke Cornelia C H Wielders Alies van Lier Wim van der Hoek Adam Meijer Gé A Donker Frederika Dijkstra Carel Harmsen Marianne A B van der Sande Mirjam Kretzschmar
author_sort	Cees C van den Wijngaard
title	Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.
title_short	Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.
title_full	Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.
title_fullStr	Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.
title_full_unstemmed	Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.
title_sort	comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/717a8511a7ac4fb6a4c28a46a87396ea
work_keys_str_mv	AT ceescvandenwijngaard comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT liselottevanasten comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT marionpgkoopmans comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT wilfridvanpelt comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT nicojdnagelkerke comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT corneliachwielders comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT aliesvanlier comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT wimvanderhoek comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT adammeijer comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT geadonker comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT frederikadijkstra comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT carelharmsen comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT marianneabvandersande comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren AT mirjamkretzschmar comparingpandemictoseasonalinfluenzamortalitymoderateimpactoverallbuthighmortalityinyoungchildren
_version_	1718423414613475328

Comparing pandemic to seasonal influenza mortality: moderate impact overall but high mortality in young children.

Ejemplares similares