Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

Von Willebrand factor (VWF) is a large glycoprotein in the blood secreted from endothelial cells lining the blood vessel and activation of VWF leads to formation of VWF-platelet complexes or thrombi. Here authors use single-molecule force measurement, X-ray crystallography and functional measurement...

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Autores principales:	Nicholas A. Arce, Wenpeng Cao, Alexander K. Brown, Emily R. Legan, Moriah S. Wilson, Emma-Ruoqi Xu, Michael C. Berndt, Jonas Emsley, X. Frank Zhang, Renhao Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/717c9b35a0aa4d4d8a77c1b7e9fbb9c1
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spelling	oai:doaj.org-article:717c9b35a0aa4d4d8a77c1b7e9fbb9c12021-12-02T17:33:40ZActivation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module10.1038/s41467-021-22634-x2041-1723https://doaj.org/article/717c9b35a0aa4d4d8a77c1b7e9fbb9c12021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22634-xhttps://doaj.org/toc/2041-1723Von Willebrand factor (VWF) is a large glycoprotein in the blood secreted from endothelial cells lining the blood vessel and activation of VWF leads to formation of VWF-platelet complexes or thrombi. Here authors use single-molecule force measurement, X-ray crystallography and functional measurements to monitor the activation of VWF via mechanical unfolding of the autoinhibitory module (AIM).Nicholas A. ArceWenpeng CaoAlexander K. BrownEmily R. LeganMoriah S. WilsonEmma-Ruoqi XuMichael C. BerndtJonas EmsleyX. Frank ZhangRenhao LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas A. Arce Wenpeng Cao Alexander K. Brown Emily R. Legan Moriah S. Wilson Emma-Ruoqi Xu Michael C. Berndt Jonas Emsley X. Frank Zhang Renhao Li Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
description	Von Willebrand factor (VWF) is a large glycoprotein in the blood secreted from endothelial cells lining the blood vessel and activation of VWF leads to formation of VWF-platelet complexes or thrombi. Here authors use single-molecule force measurement, X-ray crystallography and functional measurements to monitor the activation of VWF via mechanical unfolding of the autoinhibitory module (AIM).
format	article
author	Nicholas A. Arce Wenpeng Cao Alexander K. Brown Emily R. Legan Moriah S. Wilson Emma-Ruoqi Xu Michael C. Berndt Jonas Emsley X. Frank Zhang Renhao Li
author_facet	Nicholas A. Arce Wenpeng Cao Alexander K. Brown Emily R. Legan Moriah S. Wilson Emma-Ruoqi Xu Michael C. Berndt Jonas Emsley X. Frank Zhang Renhao Li
author_sort	Nicholas A. Arce
title	Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
title_short	Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
title_full	Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
title_fullStr	Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
title_full_unstemmed	Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
title_sort	activation of von willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/717c9b35a0aa4d4d8a77c1b7e9fbb9c1
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Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module

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